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EC number: 202-811-7 | CAS number: 100-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data on the acute toxicity of 4-nitrophenol (oral, dermal and inhalation route) has been reviewed in several reports; the information of which is provided under "discussion".
According to regulation (EC) No 1272/2008 on classification. labelling and packaging of substances and mixtures, p-nitrophenol (4-nitrophenol) is officially classified as acute oral, dermal and inhalation toxicity category 4 (H302, H312 and H332).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Value:
- 0.005 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Additional information
In the Concise International Chemical Assessment Document (CICAD) on Mononitrophenols (2 -nitrophenol and 4 -nitrophenol) the LD50 values after single oral administration of 4 -nitrophenol are cited to be in the range of 220 - 620 mg/kg bw in rats and 380 - 470 mg/kg bw in mice.
As well in the BUA report, toxicity data on 4 -nitrophenol are reviewed. The acute oral LD50 is cited to be in the range of 220 -620 mg/kg bw in rats.
In the toxicological profile on mononitrophenols, toxicology data on 4 -nitrophenol are reviewed. Five acute oral toxicity studies are cited, three of which were performed in rats, one in rabbits and one in mice. The resulting LD50 values were in the range of 230 -667 mg/kg bw in rats and cited to be 220 and 470 mg/kg in rabbits and mice, respectively.
For acute inhalation toxicity, it is cited in CICAD that no mortalities were observed in rats exposed to 4700 mg/m3when applied as dust (sodium salt) for 4 hours. In four of six rats, a corneal opacity was observed at the end of the exposure which persisted throughout the 14-day observation period. In another inhalation study, rats were exposed to an atmosphere saturated with the test substance for 8 hours and no mortality and no signs of toxicity were reported.
The dermal LD 50 for rats and guinea pigs is cited to be ≥ 1000 mg/kg bw in CICAD. In the BUA report, the LD50 of 4-nitrophenol after dermal application is cited to be in the range of 1024-1300 mg/kg bw in rats.
According to regulation (EC) No 1272/2008 on classification. labelling and packaging of substances and mixtures, p-nitrophenol (4-nitrophenol) is officially classified as acute oral, dermal and inhalation toxicity category 4 (H302, H312 and H332).
Justification for classification or non-classification
According to regulation (EC) No 1272/2008 on classification. labelling and packaging of substances and mixtures, p-nitrophenol (4-nitrophenol) is officially classified as acute oral, dermal and inhalation toxicity category 4 (H302, H312 and H332).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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