Registration Dossier
Registration Dossier
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EC number: 266-027-7 | CAS number: 65996-92-1 The distillate from coal tar having an approximate distillation range of 100°C to 450°C (212°F to 842°F). Composed primarily of two to four membered condensed ring aromatic hydrocarbons, phenolic compounds, and aromatic nitrogen bases.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
For anthracene oil containing less than 50 ppm of BaP, weakly mutagenic potential may be observed in vitro:
an Ames test in the presence of metabolising enzymes was positive only in TA 100 at cytotoxic concentrations;
a mouse-lyphoma assay (MLA, OECD 476) weakly positive for a closely structure-related tar oil;
a cytogenetic assay (chromosomal aberration, OECD 473) came out negative for the very same tar oil.
An in-vivo micronucleus test in mice using the structure-related tar oil gave no evidence of a mutagenic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The low-grade mutagenic potential eventually detected in in-vitro standard assays conducted with tar oils containing BaP levels of =< 50 ppm has not been confirmed in an mammalian erythrocyte micronucleus assay.
Anthracene oil (BaP =< 50 ppm) is supposed to reflect similar mutagenic properties.
Thus classification according to Regulation (EC) No 1272/2008 or Directive (EU) 67/548/EEC is not required.
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