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EC number: 219-417-6
CAS number: 2432-99-7
A calculated value is available: logKow = -0.16. In order to test the applicability of the model for the substance of interest and so to validate the model for aminoacids, logKow of other aminoacids have been calculated using the EPIWIN program (KowWin v1.67 fragment description) and compared with the experimental data reported in the same model. The results are as follows : For 6 aminohexanoic acid (60-32-2): logKow (estimated) = - 2.62 logKow (experimental) : -2.95 For 8-aminooctanoic acid (1002-57-9): logKow (estimated) = -1.64 Experimental logKow = - 2,55The estimated logKow values are similar to the experimental data reported in the same model, showing that the model is applicable to this type of aminoacids.
As the applicability of the EPIWIN program
(KowWin v1.67) for the estimation of log Kow
values of aminoacids has been demonstrated, this calculated value is
considered acceptable and its reliability is considered as "2".
Considering the log Kow value of -0.16, 11-aminoundecanoic
acid has a low potential for bioaccumulation.
According to the Guidance on information
requirements and chemical safety assessment Chapter R.7a: Endpoint
specific guidance (ECHA, 2008), the impact of errors on model
predictions for a logKow value below 1 is usually less critical.
Moreover, the value estimated is outside the applicability range of the
reverse phase HPLC method (OECD GL 117) and very closed to the lowest
value of the applicability range of the shake flask method (OECD GL
107). Therefore, it is considered that an experimental study is not
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