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EC number: 219-417-6
CAS number: 2432-99-7
- About 10% of the applied radioactivity was
recovered within 24h in the urine of treated animals.
- Some radioactivity (not quantitated) was
found in the soda lime, indicating that minor amounts of 14CO2 had been
produced by metabolism of
14C-11 -aminoundecanoic acid
- Thin layer chromatography pattern were
different within male and female. Both sex of F-344 rats metabolised
differently the 11 -aminoundecanoic
The excretion of radioactivity derived from 11aminoundecanoic acid is slow; only some 10% of the dose was excreted in urine and feces during the
first 24 h after dosing (Tab. 1).In addition, minor amounts of radioactivity (not quantitated) were excreted in breath, apparently as 14C02 (in the CO2
soda lime trapping). Table 1: Total radioactivity (dpm) in urine and feces after 24 hours of a single oral dose of 11-aminoundecanoic acid as
determined by liquid scintillation counting of aliquots (0.1 ml urine/50 µg feces
F-344 rats, female
F-344 rats, male
1.01 x10e8 (+)
3.15 x10e7 (+)
1.65 x10e8 (+)
1.64 x10e8 (+)
1.89 x10e 8
(+) feces contaminated with urine(++) female No. 2 received only 1/2 doseTable 2: Percent of radioactivity dose excreted within 24 h (x+S.D.):
6.7 ± 4.3
9.6 ± 2.8
3.3 ± 3.8
1.9 ± 2.0
urine + feces
9.9 ± 7.2
11.5 ± 4.0
The purpose of the study was to determine whether
AA is excreted in major amounts in unmetabolized form by this species.
During a DNA binding study (Bolt H.M.,
1987), 24h-urine samples were collected and deep-frozen for further
analyses. Then, these urine samples were used for investigating the
metabolism of 11 -aminoundecanoic acid excretion products. After one
single oral administration (gavage) of 1mCi of labelled
11-aminoundecanoic acid in 5 male and 5 female F-344 rats, it was shown
that the substance is excreted in urine.
According the the results, less than 20% of the administered
radiocatively labelled AA was excreted unchanged in the urine by rats.
It was also demonstrated that 80% of the urinary excretion products were
Excretion patterns are different between
male and female.
However, the main product seems to be
identical for both males and females.
Metabolites were not identified. The
metabolic conversion which resulted in the main excretory product must
have taken place in the N-terminal part of the substance. Possible
metabolic reactions are : oxidative deamination, acetylation and
conjugation with glucuronic acid / glutathione.
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