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EC number: 220-479-1
CAS number: 2781-00-2
One key study is available for each of
the trophic compartments: Algae, Aquatic invertebrates and Fish: no
effect of 1,4-bis(tert-butylperoxyisopropyl)benzene was observed up to
its water solubility limit (0.04 mg/l).As a consequence, we propose to
consider this water solubility limit as a NOEC value for the three
considered trophic compartments. Then, we propose to use an assessment
factor of 10 as recommended when NOEC are available for the three
So and first of all, based on the full
required set, 1,4-bis(tert-butylperoxyisopropyl)benzene has no effect
and not only just no EC50 at the limit of solubility.The algae
NOEC/ERC10 can also be considered not as a true NOEC but as a no effect
at the maximum solubility tested. So first we are actually basing our
factor of 10 on a no effect at all concentration (NEAAC) and not a NOEC.
Second, there are many substances for
which the algae compartment is considered as the most sensitive species
tested.This assumption relies on the fact that the substance having a
direct effect on cell membranes, which makes small (unicellular)
organisms more sensitive than larger ones. For these reasons, and if we
consider algae as the most sensitive trophic compartment, the NOEC for
the most sensitive species is available even if no chronic toxicity test
results are available at the moment.
Third, there may be cases where we
don’t expect algae to be more sensitive than the other species. For
non-polar narcotics, the three studies tend to provide similar
NOECs/EC10s. This is very clear for the algae, daphnid, fish non-polar
narcotic QSARs which are almost identical.
For chronic studies there may be some
differences between the QSARs but following critical body burden theory
(Eisenbud, 1973; Foulkes, 1990), there is no reason why there would be a
difference. Biological membrane disruption occurs at the same molar
concentration but it can take a different time to reach those internal
body residue concentrations.
That is the reason why we propose to
consider the NOEC for algae as a NEAAC applicable to the three trophic
compartments. Based on this assumption we propose to use an assessment
factor of 10 as recommended when a NOEC value is available for the three
To summarize no effect of
1,4-bis(tert-butylperoxyisopropyl)benzene was observed up to its water
solubility limit (0.04 mg/l).
1,4-bis(tert-butylperoxyisopropyl)benzene is not readily biodegradable
(OECD 301D) and its log Kow was estimated at 7.3.
That is the reason why according to
67/548/ECC, 1,4-bis(tert-butylperoxyisopropyl)benzene is classified R53.
According to CLP the substance is classified
"Aquatic chronic category 4".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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