Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
No substance specific data on metabolism and kinetics are available. Based on physical-chemical characteristics, no or only limited absorption by the dermal and inhalation routes is expected, whereas oral absorption is more likely.

Key value for chemical safety assessment

Bioaccumulation potential:
high bioaccumulation potential

Additional information

No substance specific data on metabolism and kinetics are available, neither in human nor in animal.

Based on physical-chemical characteristics, particularly low water solubility (<0.62 mg/l), octanol-water partition coefficient (experimental log Kow is > 5.5, calculated log Kow :7.3) and low vapour pressure ( 9 x 10-7 mbars at 20°C), no or only limited absorption by the dermal and inhalation routes is expected, which is further supported by the acute dermal toxicity study results. Moreover the substance is not a skin irritant; therefore no increase of skin absorption is expected.

Based on this log Pow a logBCF was calculated: 3.96 (EPIWIN)

Based on the high log Kow and the very low water solubility, the substance can be regarded as a lipophilic substance. Such a lipophilic compound may be taken up by micellular solubilisation by oral route exposure. Inhalation is not likely since the substance is a powder, and with regards to granulometry.