Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
Anonymous
Year:
2000
Bibliographic source:
IUCLID4 data set for trisodiumnitrilotriacetate, 18 February 2000, page 169

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrilotriacetic acid
EC Number:
205-355-7
EC Name:
Nitrilotriacetic acid
Cas Number:
139-13-9
Molecular formula:
C6H9NO6
IUPAC Name:
2-[bis(carboxymethyl)amino]acetic acid

Test animals

Species:
rabbit
Strain:
New Zealand White

Administration / exposure

Type of coverage:
open
Vehicle:
water
Duration of treatment / exposure:
28 days
Frequency of treatment:
on each working day (20 days)
Doses / concentrations
Remarks:
Doses / Concentrations:
2.5% aqueous solution (50 mg/kg) as Na3NTA
Basis:
nominal per unit body weight
No. of animals per sex per dose:
6 animals in total, of which 3 treated and 3 not tretaed
Control animals:
yes, concurrent no treatment

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
37 mg/kg bw/day (nominal)
Based on:
test mat.
Basis for effect level:
other: Effect level expressed as the acid

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No local or systemic effects

Applicant's summary and conclusion