Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Guideline:
- other: QSAR
- GLP compliance:
- not specified
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Dose descriptor:
- LD50
- Effect level:
- 1 580 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effect level expressed as the acid
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 580 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
At least 25 different sudies regarding the acute oral toxicity in rats of nitrilotriacetic acid and its salts are known. The results vary widely (between 800 mg/kg and more than 6400 mg/kg), but so do the respective reliabilities. The bulk of the oral toxicity data in rats lie between 800 and 2000 mg/kg, confirming a classification according to CLP of "Acute Oral Toxicity Category 4".
The study mentioned in this endpoint is an average.
There are no acute dermal toxicity studies studies available.
The acute inhalation toxicty in rats is above 3.7 mg/l (exposure time 4 hours). The substance was offered as micronised material in air (due to the very low volatility of this substance).
Oral LD50 studies in other species (mouse, rabbit, dog, guinea pig and monkey) are also available but of questionable reliability. Worth mentioning are the two studies in monkeys with an LD50 of 750 mg/kg.
A number of intra peritoneal LD50 and LC50 studies are available in rat and mouse with values between 175 and 500 mg/kg bw. Also their reliability is questionable.
(All effect levels are expressed as the acid. All mentioned studies can be checked in the IUCLID4 dossier for trisodiumnitrilotriacetate which is attached in section 13)
Justification for classification or non-classification
At the effect level found the substance must be classified according to CLP for acute oral toxicity category 4
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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