Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: modified Draize method
GLP compliance:
no
Type of study:
Draize test
Species:
human
Concentration / amount:
1% of an aqeous solution of a detergent containing 20% NTA
Concentration / amount:
1% of an aqeous solution of a detergent containing 20% NTA
No. of animals per dose:
66
Reading:
1st reading
Hours after challenge:
336
Group:
test chemical
Dose level:
0.2%
No. with + reactions:
0
Total no. in group:
66
Clinical observations:
None. The reading was 2 weeks after a 9-fold induction (3 x per week)
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 336.0. Group: test group. Dose level: 0.2%. No with. + reactions: 0.0. Total no. in groups: 66.0. Clinical observations: None. The reading was 2 weeks after a 9-fold induction (3 x per week).
Interpretation of results:
not sensitising
Remarks:
Migrated information
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

No adverse effect observed, so no requirement for classification.