Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A QSAR model, ECOSAR was used to estimate long-term toxicity to fish.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the long-term toxicity to fish. The following measured values were used in the model: log Kow = 4.0, water solubility = 530 mg/L and melting point = -0.9 C.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
SMILES notation used: Oc1ccccc1C(CC)(C)C

Test organisms

Test organisms (species):
other: fish

Study design

Water media type:
freshwater

Results and discussion

Effect concentrations
Duration:
30 d
Dose descriptor:
other: chronic value (geometric mean of NOEC and LOEC)
Effect conc.:
0.117 mg/L
Details on results:
As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.082 mg/L and will be used in the assessment.

Applicant's summary and conclusion

Conclusions:
Using a reliable QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the 30d ChV for fish to be 0.117 mg/L.
Executive summary:

A reliable QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 1.11) was used to predict the chronic aquatic toxicity of o-tert-Amylphenol (otAP) to fish. The 30 day chronic value (the geometric mean of the NOEC and LOEC) were 0.117 mg/L and 0.262 mg/L for the phenols class and neutral organic class, respectively. Since o-tert-amylphenol is in the class of phenols, the result for the phenol class will be used as key for long-term toxicity to fish. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.083 mg/L and will be used in the assessment.