Registration Dossier
Registration Dossier
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EC number: 279-317-3 | CAS number: 79828-43-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- EC Number:
- 279-317-3
- EC Name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- Cas Number:
- 79828-43-6
- Molecular formula:
- C38H18Cl2CrN16O20S4.5Na
- IUPAC Name:
- Pentasodium bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Strain: NMRI/WIGA
- Fasting: 15 to 29 hours
- Diet: HERILAN MRH-HALTUNG; H.EGGERSMANN KG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- Concentration in vehicle [%]: 3.16, 4.64, 7, 10
Application volume: 10 ml/kg bw - Doses:
- 316, 464, 700, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation: 1 hour and 1, 2, 7, 14 days after administration
- Body weight: Start of study, Days 2-4, 7, 13
- Necropsy of survivors performed: yes - Statistics:
- LD50 determination, test for dose-effect relation, Probit analysis, test for homogeneity of data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 611 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 507 - 737
- Mortality:
- Dose [mg/kg bw] No of animals No dead animals mortality [%]
316 10 0 0
464 10 3 30
700 10 5 50
1000 10 10 100 - Clinical signs:
- dyspnoea, blue discoloration of skin and urine, ataxia, apathia, prone position, tremor, convulsions, exsiccosis
- Body weight:
- no effect
- Gross pathology:
- discolouration of organs, intraabdominal precipitation of test substance
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 in the mouse is 611 mg/kg bw
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