Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Compliance

Data source

Reference
Reference Type:
other: Body responsible for test
Title:
Unnamed
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 84.449.EWG, B.3
GLP compliance:
yes
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat, Tif.RAlf (SPF)

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Erdnussol
Duration of exposure:
24h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000mg/kg bw; number of animals: 6; number of deaths: 0
Female: 2000mg/kg bw; number of animals: 5; number of deaths: 0
Clinical signs:
Unspecific symptoms of intoxication, reversible within 8 days in all animals.
Gross pathology:
Effects on organs: No findings
Other findings:
Signs of toxicity (local): No findings

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Not considered harmful
Executive summary:

Due to the lack of information provided by ECHA, it is difficult to assess this end point fully. It appears from information provided that the substance has low toxicity.