Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Compliance

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 84/449/EWG, C.1
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Identity and cncentration of auxilliary solvent for dispersal : 25 ml standard solution containing 3g test substance and 80 mg of alkylphenol-polyglycolether in N-methyl pyrollidone

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
semi-static

Test conditions

Hardness:
175 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
0.47 mg/L
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.46 mg/L
Basis for effect:
mortality
Duration:
72 h
Dose descriptor:
LC50
Effect conc.:
0.46 mg/L
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.46 mg/L
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
0.3 mg/L
Details on results:
% concentration loss over test : 82 to 95

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
Met criteria for notificatrion by CA
Conclusions:
Very toxic to aquatic organisms
Executive summary:

Only limited data has been provided by ECHA, but it is apparent that the substance was poorly stable under the conditions of the study, despite using semi-static method for renewal of test media. It is known that the substance is very unstable in light and it can be assumed that the toxicity was as a result of exposure to one or more of the abiotic metabolites. This method of exposure is considered valid for risk assessment.