Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
215-540-4
CAS no.:
1330-43-4
Index number:
Molecular formula:
B4Na2O7
SMILES:
[Na+].[Na+].[O-]B1OB2OB([O-])OB(O1)O2
InChI:
InChI=1S/B4O7.2Na/c5-1-7-3-9-2(6)10-4(8-1)11-3;;/q-2;2*+1
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
24
Of which contain:
3 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may damage fertility or the unborn child and causes serious eye irritation.

This substance is covered by several Harmonised Classifications and Labelling's (CLH) entries approved by the European Union. Differentiating between the different CLH's entries requires manual verification. To know more about the CLH please visit the C&L Inventory.

Breakdown of all 1636 C&L notifications submitted to ECHA

Repr. 1B H360
Eye Irrit. 2 H319
Repr. 2 H360
Repr. 1A H360
Acute Tox. 4 H302
Acute Tox. 1 H330
Acute Tox. 4 H312
Eye Dam. 1 H318
Repr. 1B H360FD
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R
Officially recognised in the EU as Toxic to Reproduction (Harmonised C&L, Candidate list of SVHCs).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 23 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 22 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: wood preservation, wood preservation, wood preservation.

This substance is used in the following products: anti-freeze products, heat transfer fluids, lubricants and greases and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens), high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), the low energy manipulation of substances bound in materials or articles, open transfer and processing with minerals/metals at elevated temperature and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: inks and toners, fertilisers, photo-chemicals, washing & cleaning products, coating products, biocides (e.g. disinfectants, pest control products) and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: building & construction work, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, treatment of articles by dipping and pouring, mixing in open batch processes, closed batch processing in synthesis or formulation, non-industrial spraying, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, hand mixing with intimate contact only with personal protective equipment available and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: pH regulators and water treatment products, metal working fluids and lubricants and greases. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, mixing in open batch processes, closed processes with no likelihood of exposure and potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation in materials and manufacturing of the substance.

This substance is used in the following products: pH regulators and water treatment products, water treatment chemicals and welding & soldering products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging and building & construction work. This substance is used for the manufacture of: chemicals, mineral products (e.g. plasters, cement), machinery and vehicles, fabricated metal products and metals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, mixing in open batch processes, closed processes with no likelihood of exposure and potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens).

Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, in processing aids at industrial sites, manufacturing of the substance and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, transfer of substance into small containers, open transfer and processing with minerals/metals at elevated temperature and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, formulation of mixtures and in the production of articles.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • Aries S.p.A., Via Egadi, 5 20144 Milano Italy
  • AS DBT, Narva mnt 7D 10117 Tallinn Estonia
  • B-Lands Consulting (811232-9), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • Borax Europe Limited, 6 St. James's Square SW1Y 4AD London United Kingdom
  • Chemische Fabrik Budenheim KG, Rheinstrasse 27 55257 Budenheim RLP Germany
  • Cummins NV, 49-51 Gresham Road TW18 2BD Staines Middlesex United Kingdom
  • ETIMINE SA, 204, Zone Industrielle Scheleck 2 L-3225 Bettembourg Luxembourg Luxembourg
  • Experien Chemical Services (Europe) Limited, PO Box 170 YO7 9AN Thirsk United Kingdom
  • Ferro France S.A.R.L., 43 rue Jeanne d'Arc 52115 Saint-Dizier Cedex France
  • Haifa North West Europe BVBA-SO, Generaal de Wittelaan 17, bus 16 B-2800 Mechelen Belgium
  • Industrie Bitossi, via Pietramarina, 53 50053 sovigliana-vinci (FI) Italy
  • LTS-REACH-OR-ANS, 43 rue Laroque 33560 Sainte Eulalie France
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • OR SEARLES VALLEY MINERALS, 164 avenue Joseph Kessel Centre d'affaires Parkile - Bat 2 78960 Voisins Le Bretonneux France
  • PHARMEGIC HEALTHCARE LIMITED, Unit 23, Trinity Technology and Enterprise campus, Pearse Street D02WR66 Dublin 2 Ireland
  • Quality Chemicals S.L., C/ Fornal, 35, Pol. Ind. Can Comelles-Sud 08292 Esparreguera Barcelona Spain
  • Rio Tinto Iron & Titanium GmbH (5), Mergenthalerallee 77 65760 Eschborn Hesse Germany
  • SCL ITALIA S.P.A., Via Fabio Filzi 25/A 20124 Milan Italy
  • Services Techniques Schlumberger_OR 12, 1, Cours du Triangle 92936 La Défense France
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Vesuvius UK Ltd, 1 Midland Way Central Park S43 4XA Barlborough Links Derbyshire United Kingdom
  • [Confidential], [Confidential]
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Solenis Netherlands B.V., Fascinatio Boulevard 522 2909 VA CAPELLE A/D IJSSEL Netherlands

Substance names and other identifiers

Borax
Other
Boric acid(H2B4O7), disodium salt, pentahydrate
Other
boric acid, disodium salt
C&L Inventory, EU. Dangerous Substances - Eco-Labels
Boron sodium oxide (B4Na2O7), pentahydrate
Other
Boron sodium oxide(B4Na2O7), pentahydrate
Other
disodium tetraborate decahydrate; borax decahydrate
EU. Worker Protection-Hazardous (98/24), EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
disodium tetraborate pentahydrate; borax pentahydrate
EU. Worker Protection-Hazardous (98/24), EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
disodium tetraborate, anhydrous; boric acid, disodium salt
EU. Worker Protection-Hazardous (98/24), EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Kathon 886
Other
Mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-methylisothiazol-3(2H)-one
EU. Cosmetics Regulation Annex V, Allowed Preservatives
Reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)
EU. Substances Restricted in Toy
reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7]and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1) with reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7]and 2-methyl-4-isothiazolin-3-one [EC no. 220-239-6] (3:1)
EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs
reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7]and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1); reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7]and 2-methyl-4-isothiazolin-3-one [EC no. 220-239-6] (3:1)
EU. Worker Protection-Hazardous (98/24), EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Sodium borate
EU. Cosmetics Regulation, Annex II, Prohibited Substances
Sodium borate, pentahydrate
Other
Sodium tetraborate
Other, EU. Com. Reg. No 10/2011 on plastic materials in contact with food
Sodium tetraborate pentahydrate
Other
acid boric, sare disodică(borat de sodiu) (ro)
C&L Inventory
acide borique anhydrique, sel de disodium (fr)
C&L Inventory
acido borico, sale disodico (it)
C&L Inventory
aċidu boriku, melħ disodju (mt)
C&L Inventory
bezvodý tetraboritan disodný (sk)
C&L Inventory
booraksdekahüdraat (et)
C&L Inventory
booraksidekahydraatti (fi)
C&L Inventory
booraksipentahydraatti (fi)
C&L Inventory
boorakspentahüdraat (et)
C&L Inventory
boorhape, dinaatriumsool (et)
C&L Inventory
boorihapon dinatriumsuola (fi)
C&L Inventory
boorzuur, dinatriumzout (nl)
C&L Inventory
borace decaidrato (it)
C&L Inventory
borace pentaidrato (it)
C&L Inventory
boraka dekahidrāts (lv)
C&L Inventory
boraka pentahidrāts (lv)
C&L Inventory
boraks dekahidrat (hr)
C&L Inventory
boraks pentahidrat (hr)
C&L Inventory
boraksdecahydrat (no)
C&L Inventory
borakso dekahidratas (lt)
C&L Inventory
borakso pentahidratas (lt)
C&L Inventory
borakspentahydrat (no)
C&L Inventory
borax decahidratat (ro)
C&L Inventory
borax decahydrat (da)
C&L Inventory
borax decahydrate (mt)
C&L Inventory
borax dekahydrát (cs)
C&L Inventory
borax décahydrate (fr)
C&L Inventory
borax pentahidratat (ro)
C&L Inventory
borax pentahydrat (da)
C&L Inventory
borax pentahydrate (fr)
C&L Inventory
borax pentahydrát (cs)
C&L Inventory
boraxdecahydraat (nl)
C&L Inventory
Boraxdecahydrat (de)
C&L Inventory
boraxdekahydrat (sv)
C&L Inventory
boraxpentahydraat (nl)
C&L Inventory
Boraxpentahydrat (de)
C&L Inventory
borna kiselina, dinatrijeva sol (hr)
C&L Inventory
boro rūgšties dinatrio druska (lt)
C&L Inventory
borova kislina, dinatrijeva sol (sl)
C&L Inventory
borskābe, dinātrija sāls (lv)
C&L Inventory
borsyra, dinatriumsalt (sv)
C&L Inventory
borsyre, dinatriumsalt (no)
C&L Inventory
borsyredinatriumsalt (da)
C&L Inventory
Borsäure, Dinatriumsalz (de)
C&L Inventory
bórax deca-hidratado (pt)
C&L Inventory
bórax penta-hidratado (pt)
C&L Inventory
bórax, decahidrato (es)
C&L Inventory
bórax, dekahydrát (sk)
C&L Inventory
bórax, pentahidrato (es)
C&L Inventory
bórax, pentahydrát (sk)
C&L Inventory
bórax-dekahidrát (hu)
C&L Inventory
bórax-pentahidrát (hu)
C&L Inventory
bórsav, dinátrium-só (hu)
C&L Inventory
dekahydrat boraksu (pl)
C&L Inventory
dekahydrat tetraboranu disodu (pl)
C&L Inventory
dekahydrát tetraboritanu disodného (sk)
C&L Inventory
Dinaatriumtetraboraat (et)
Biocidal active substances
dinaatriumtetraboraat, veevaba (et)
C&L Inventory
dinaatriumtetraboraatdekahüdraat (et)
C&L Inventory
dinaatriumtetraboraatpentahüdraat (et)
C&L Inventory
Dinatrijev oktaborat tetrahidrat (hr)
Biocidal active substances
Dinatrijev tetraborat (hr)
Biocidal active substances
dinatrijev tetraborat dekahidrat (hr)
C&L Inventory
dinatrijev tetraborat dekahidrat, (sl)
C&L Inventory
Dinatrijev tetraborat pentahidrat (hr)
C&L Inventory, Biocidal active substances
dinatrijev tetraborat pentahidrat, (sl)
C&L Inventory
dinatrijev tetraborat, bezvodni (hr)
C&L Inventory
dinatrijev tetraborat, brezvodni (sl)
C&L Inventory
Dinatrio tetraboratas (lt)
Biocidal active substances
dinatrio tetraboratas, bevandenis (lt)
C&L Inventory
dinatrio tetraborato dekahidratas (lt)
C&L Inventory
dinatrio tetraborato pentahidratas (lt)
C&L Inventory
Dinatriumtetraboraat (nl)
Biocidal active substances
dinatriumtetraboraat, watervrij (nl)
C&L Inventory
dinatriumtetraboraatdecahydraat (nl)
C&L Inventory
dinatriumtetraboraatpentahydraat (nl)
C&L Inventory
Dinatriumtetraboraatti (fi)
Biocidal active substances
Dinatriumtetraboraatti, vedetön (fi)
C&L Inventory
Dinatriumtetraboraattidekahydraatti (fi)
C&L Inventory
Dinatriumtetraboraattipentahydraatti (fi)
C&L Inventory
Dinatriumtetraborat (da)
Biocidal active substances
dinatriumtetraborat decahydrat (da)
C&L Inventory
dinatriumtetraborat pentahydrat (da)
C&L Inventory
dinatriumtetraborat, dekahydrat (sv)
C&L Inventory
dinatriumtetraborat, vandfrit (da)
C&L Inventory
dinatriumtetraborat, vannfri (no)
C&L Inventory
dinatriumtetraborat, vattenfritt (sv)
C&L Inventory
Dinatriumtetraborat, wasserfrei (de)
C&L Inventory
Dinatriumtetraboratdecahydrat (de)
C&L Inventory
Dinatriumtetraboratpentahydrat (de)
C&L Inventory
Dinátrium-tetraborát (hu)
Biocidal active substances
dinátrium-tetraborát-dekahidrát (hu)
C&L Inventory
dinátrium-tetraborát-pentahidrát (hu)
C&L Inventory
dinátrum-tetraborát, vízmentes (hu)
C&L Inventory
dinātrija tetraborāta pentahidrāts (lv)
C&L Inventory
Dinātrija tetraborāts (lv)
Biocidal active substances
dinātrija tetraborāts, bezūdens (lv)
C&L Inventory
dinātrijatetraborāta dekahidrāts (lv)
C&L Inventory
Disodium tetraborate (no)
Biocidal active substances
disodium tetraborate decahydrate (mt)
C&L Inventory, Biocidal active substances
disodium tetraborate pentahydrate (mt)
C&L Inventory, Biocidal active substances
disodium tetraborate, anhydrous (mt)
C&L Inventory
disodná sůl kyseliny ortoborité (cs)
C&L Inventory
kwas borowy, sól disodowa (pl)
C&L Inventory
kyselina boritá, disodná soľ (sk)
C&L Inventory
pentahydrat boraksu (pl)
C&L Inventory
pentahydrat tetraboranu disodu (pl)
C&L Inventory
pentahydrát tetraboritanu disodného (sk)
C&L Inventory
sal dissódico de ácido bórico (pt)
C&L Inventory
Tetraboran disodu (pl)
Biocidal active substances
tetraboran disodu, bezwodny (pl)
C&L Inventory
tetraborat de disodiu decahidratat (ro)
C&L Inventory
tetraborat de disodiu pentahidratat (ro)
C&L Inventory
tetraborat de disodiu, anhidru (ro)
C&L Inventory
Tetraborat disodic (ro)
Biocidal active substances
Tetraborat tad-disodju (mt)
Biocidal active substances
Tetraborato de disodio (es)
Biocidal active substances
tetraborato de dissódio anidro (pt)
C&L Inventory
tetraborato de dissódio decahidratado (pt)
C&L Inventory
tetraborato de dissódio pentahidratado (pt)
C&L Inventory
Tetraborato di disodio (it)
Biocidal active substances
tetraborato di disodio decaidrato (it)
C&L Inventory
tetraborato di disodio, anidro (it)
C&L Inventory
Tetraborato dissódico (pt)
Biocidal active substances
tetraborato disódico anhidro (es)
C&L Inventory
tetraborato disódico, decahidrato (es)
C&L Inventory
tetraborato disódico, pentahidrato (es)
C&L Inventory
tetraboratodi disodio pentaidrato (it)
C&L Inventory
Tetraboritan disodný (cs)
Biocidal active substances
tetraboritan disodný dekahydrát (cs)
C&L Inventory
tetraboritan disodný pentahydrát (cs)
C&L Inventory
Tetraboritan sodný (sk)
Biocidal active substances
tetraboritan sodný, bezvodý (cs)
C&L Inventory
Tétraborate de disodium (fr)
Biocidal active substances
tétraborate de disodium , anhydre (fr)
C&L Inventory
tétraborate de disodium décahydrate (fr)
C&L Inventory
tétraborate de disodium pentahydrate (fr)
C&L Inventory
ácido bórico, sal disódica (es)
C&L Inventory
δεκαένυδρο τετραβορικό δινάτριο (el)
C&L Inventory
δεκαένυδρος βόρακας (el)
C&L Inventory
Διδύναμο μετά νατρίου άλας βορικού οξέος (el)
C&L Inventory
Διδύναμο μετά νατρίου άλας τετραβορικού οξέος, άνυδρο (el)
C&L Inventory
πενταένυδρο τετραβορικό δινάτριο (el)
C&L Inventory
πενταένυδρος βόρακας (el)
C&L Inventory
Τετραβορικό νάτριο (el)
Biocidal active substances
боракс декахидрат (bg)
C&L Inventory
боракс пентахидрат (bg)
C&L Inventory
борна киселина, динатриева сол (bg)
C&L Inventory
Динатриев тетраборат (bg)
Biocidal active substances
динатриев тетраборат декахидрат (bg)
C&L Inventory
динатриев тетраборат пентахидрат (bg)
C&L Inventory
динатриев тетраборат, безводен (bg)
C&L Inventory
Boron sodium oxide (B4Na2O7)
Other
4-octylbenzoic acid
C&L Inventory
5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
Other
Anhydrous Borax, Borax Deca-Hydrate
Registration dossier
di-Sodium tetraborate anhydrous
C&L Inventory
di-Sodium tetraborate decahydrate
C&L Inventory
Disodiuim tetraborate
Registration dossier
disodium 1,7-dioxotetraboroxane-3,5-bis(olate)
C&L Inventory
Disodium [oxido (oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate decahydrate
C&L Inventory
Disodium [oxido(oxoboranyloxy)boranyl] oxy-oxobranyl oxyborinate
C&L Inventory
Disodium [oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate
C&L Inventory
disodium [oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate decahydrate
C&L Inventory
disodium bicyclo[3.3.1]tetraboroxane-3,7-bis(olate)
Registration dossier, Other
Disodium tetraborate anhydrous
C&L Inventory
Disodium tetraborate decahydrate Borax decahydrate
C&L Inventory
Disodium tetraborate,
C&L Inventory
disodium tetraborate, anhydrous boric acid, disodium salt
C&L Inventory
Disodium Tetraborate, Anydrous
C&L Inventory
Disodium tetraborate, decahydrate
C&L Inventory
Na2-tetraborate
C&L Inventory
Sodium Borate Decahydrate
C&L Inventory
Sodium Tetraborate Decahydrate
C&L Inventory
Borax 10 mol
Registration dossier
Borax 10-Hydrate
Registration dossier
Borax 5 mol
Registration dossier
borax anhydrous
Registration dossier
Borax anhydrous / Borax pentahydrate
Registration dossier
Borax Dehybor
Registration dossier
Borax EP
Registration dossier
Borax FG
Registration dossier
Borax NS
Registration dossier
DECAHYDRATE BORAX
Registration dossier
Dehybor
Registration dossier
Disodium tetraborate anhydrous EP
Registration dossier
Disodium tetraborate anhydrous FG
Registration dossier
Disodium tetraborate anhydrous NS
Registration dossier
Disodium tetraborate decahydrate EP
Registration dossier
Disodium tetraborate decahydrate FG
Registration dossier
Disodium tetraborate decahydrate NS
Registration dossier
Disodium Tetraborate Decahydrate PH Granular (Borax Decahydrate PH Granular)
Registration dossier
Disodium Tetraborate Decahydrate Technical Granular (Borax Decahydrate Technical Granular)
Registration dossier
Disodium tetraborate pentahydrate EP
Registration dossier
Disodium tetraborate pentahydrate FG
Registration dossier
Disodium tetraborate pentahydrate NS
Registration dossier
Disodium Tetraborate Pentahydrate Technical Grade Granular (Borax Pentahydrate Technical Grade Granular)
Registration dossier
Etibor-48
Registration dossier
Etibor-68
Registration dossier
Fertibor
Registration dossier
Neobor
Registration dossier
PYROBOR Dehydrated borax
Registration dossier
sodium borate anhydrous
Registration dossier
V-BOR Refined Pentahydrate Borax
Registration dossier
Vitroc
Registration dossier
005-011-00-4
Index number
C&L Inventory
005-011-01-1
Index number
C&L Inventory
005-011-02-9
Index number
C&L Inventory
1039387-27-3
CAS number
Other
115372-65-1
CAS number
Other
1186126-93-1
CAS number
Other
1189141-72-7
CAS number
Other
12045-54-4
CAS number
Other
12179-04-3
CAS number
C&L Inventory, Candidate list, Biocidal active substances, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
12322-85-9
CAS number
Other
1242163-02-5
CAS number
Other
1242163-03-6
CAS number
Other
12447-40-4
CAS number
Other
1247014-60-3
CAS number
Other
12589-17-2
CAS number
Other
1262222-67-2
CAS number
Other
1262281-53-7
CAS number
Other
1268472-42-9
CAS number
Other
1303-96-4
CAS number
C&L Inventory, Candidate list, Biocidal active substances, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
1314012-56-0
CAS number
Other
1315317-92-0
CAS number
Other
1330-43-4
CAS number
EC Inventory, C&L Inventory, Candidate list, Biocidal active substances, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Com. Reg. No 10/2011 on plastic materials in contact with food, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
1332-28-1
CAS number
Other
1344-90-7
CAS number
Other
136349-33-2
CAS number
Other
13764-83-5
CAS number
Other
1443500-22-8
CAS number
Other
163701-93-7
CAS number
Other
1820039-99-3
CAS number
Other
19223-62-2
CAS number
Other
2123562-10-5
CAS number
Other
229619-22-1
CAS number
Other
37199-25-0
CAS number
Other
55965-84-9
CAS number
Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation Annex V, Allowed Preservatives, EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Substances Restricted in Toy, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
61028-24-8
CAS number
Other
70294-89-2
CAS number
Other
71377-02-1
CAS number
Other
72980-78-0
CAS number
Other
886584-11-8
CAS number
Other
910783-70-9
CAS number
Other
910783-71-0
CAS number
Other
950582-57-7
CAS number
Other
950582-60-2
CAS number
Other
96118-96-6
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Crystalline (100%) [2]
C Odour
Odourless (100%) [2]
C Substance type
Inorganic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 2 studies processed
R Melting / freezing point
1 000 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 6 studies submitted
  • 2 studies processed
R Relative density
2 354.4 @ 26 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
-1.53 @ 22 °C and pH 7.5 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
-1.53 @ 22 °C

Water solubility

Study results
  • 8 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
49.74 g/L @ 20 °C and pH 9.69 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
49.74 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 6 studies submitted
  • 6 studies processed
C Interpretation of results
Non flammable (100%) [6]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
8.94 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
8.94

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.9 mg/L (2)
Intermittent releases (freshwater) 13.7 mg/L (2)
Marine water 2.9 mg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (2)
Sediment (freshwater) No exposure of sediment expected (2)
Sediment (marine water) No exposure of sediment expected (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 5.7 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 28 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 74 - 79.7 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other 24
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
79.7 mg/L
LC50 for marine water fish
74 mg/L

Long–term toxicity to fish

Study results
  • 32 studies submitted
  • 22 studies processed
P/RResults
NOEC (34 days) 6.4 mg/L [6]
NOEC (32 days) 11.2 - 44.5 mg/L [4]
LOEC (32 days) 23 mg/L [2]
EC10 (34 days) 6.9 - 18 mg/L [4]
LC10 (34 days) 18.3 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 22
Other 10
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 68 studies submitted
  • 46 studies processed
P/RResults
LC50 (4 days) 64 - 544 mg/L [30]
LC50 (48 h) 91 - 165 mg/L [16]
NOEC (4 days) 103 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 46
Other 22
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 24 studies submitted
  • 20 studies processed
P/RResults
NOEC (42 days) 6.6 - 25.9 mg/L [6]
NOEC (28 days) 16.6 - 43.3 mg/L [24]
NOEC (21 days) 6 - 34.2 mg/L [18]
NOEC (14 days) 13.8 - 14.3 mg/L [12]
NOEC (12 days) 33.1 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 20
Other 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 50 studies submitted
  • 4 studies processed
P/RResults
EC50 (72 h) 40.2 - 66 mg/L [8]
NOEC (72 h) 17.5 - 27.9 mg/L [6]
LOEC (62.4 h) 70.1 mg/L [2]
EC10 (72 h) 24.5 - 50.7 mg/L [8]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 2 44
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (10 days) 6.5 mg/L [2]
LOEC (10 days) 3.6 - 19.5 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 18 studies submitted
  • 16 studies processed
P/RResults
EC50 (3 h) 175 - 10 000 mg/L [4]
NOEC (72 h) 10 - 20 mg/L [8]
NOEC (7 h) 100 mg/L [2]
NOEC (3 h) 17.5 - 20 mg/L [4]
LOEC (72 h) 20 - 25 mg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 16
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
10 mg/L

Sediment toxicity

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
NOEC (28 days) 37.7 - 201.6 mg/kg sediment dw [18]
NOEC (28 days) 20 - 43 mg/L [10]
NOEC (21 days) 80.6 - 284 mg/kg sediment dw [4]
LOEC (28 days) 37.7 mg/kg sediment dw [2]
LOEC (28 days) 40 - 43 mg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 18 studies submitted
  • 18 studies processed
P/RResults
NOEC (63 days) 19.8 - 78.8 mg/kg soil dw [16]
NOEC (56 days) 5.2 - 98 mg/kg soil dw [20]
NOEC (28 days) 174.8 - 315 mg/kg soil dw [8]
NOEC (14 days) 175 mg/kg soil dw [4]
EC10 (56 days) 70.1 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 18
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
NOEC (35 days) 21.9 - 175 mg/kg bw [12]
NOEC (21 days) 174.8 mg/kg soil dw [2]
NOEC (16 days) 98.2 mg/kg soil dw [2]
EC10 (28 days) 13.8 - 68.1 mg/kg bw [8]
EC10 (21 days) 47.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 46 studies submitted
  • 4 studies processed
P/RResults
NOEC (60 days) 5 mg/kg soil dw [2]
NOEC (21 days) 5.25 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 42
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
NOEC (28 days) 419.6 mg/kg soil dw [2]
EC10 (3.4 months) 15.4 - 17.2 mg/kg soil dw [4]
EC10 (28 days) 3 - 226 mg/kg soil dw [12]
EC50 (3.4 months) 17.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 6
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.7 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 316.4 mg/kg bw/day -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.4 mg/m³ developmental toxicity / teratogenicity
Acute /short term: - -
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 159.5 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 790 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 790 µg/kg bw/day developmental toxicity / teratogenicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 26 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.5 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 28 studies submitted
  • 6 studies processed
P/RResults
LD50 2 500 - 4 080 mg/kg bw (rat) [8]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 6
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 10 studies submitted
  • 6 studies processed
P/RResults
LC50 (5 h) 2.03 mg/L air (rat) [2]
LC50 (4 h) 2.04 - 2.12 mg/L air (rat) [4]
M/CInterpretations of results
Other [6]

inhalation
Studies with data
Key study 6
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 6 studies submitted
  • 4 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [4]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 500 mg/kg bw
Inhalation route:
No adverse effect observed LC50 2 000 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study 10
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: eye
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 4
Supporting study 12
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 42 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 17.5 - 100 mg/kg bw/day [4]
LOAEL (rat): 58.5 - 334 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 40
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 81.4 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 40 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study 34
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed NOAEL 935 mg/kg bw/day (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant