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EC number: 279-087-4 | CAS number: 79135-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February the 20th to June the 20th, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Principles of method if other than guideline:
- METI method
- GLP compliance:
- not specified
- Details on sampling:
- PREPARATION OF FISH SAMPLE
Fish body weight and length were measured. Tissues were suspended in n-hexane (180 ml), homogenized for 10 minutes and centrifugated (8000 rpm for 5 minutes); at the end of this phase, n-hexane was removed.
Residues were suspended in acetone-chloroform (1 : 1, 180 ml), homogenized for 10 minutes and centrifugated (8000 rpm for 5 minutes); at the end of this phase, acetone-chloroform part was removed.
Residues were suspended in DMF (150 ml), homogenized for 10 minutes and centrifugated (8000 rpm for 10 minutes); the treatment was repeated twice. At the end of this phase, residues were separated.
The test sample was dissolved in DMF, making a volume, analysed by HPLC. After addition of test sample to fish body, the obtained recovery rate was 71.9 % by the above treatment.
PREPARATION OF WATER SAMPLE
10 ml of sample was collected from concentration level 1; condensation was perfromed with 0.5 ml rotary evapourator; after filtration by glass filter, sample was analysed by HPLC.
100 ml of sample was collected from concentration level 2; condensation was perfromed with 0.5 ml rotary evapourator; after filtration by glass filter, sample was cleaned up by coloumn chromatography. - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Japanese Killifish.
- Fish weight: 25 g - Route of exposure:
- aqueous
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 56 d
- Test temperature:
- 25.0 ± 0.5 °C
- pH:
- 7.5 ± 3.5
- Dissolved oxygen:
- 6.35 ± 0.85 mg/l
- Details on test conditions:
- RANGE-FINDING / PRELIMINARY STUDY
48 hrs TLm > 1000 ppm
During the TL,m test no death occurred at the concentrations of 100, 500 and 1000 ppm.
- Other justification for choice of test concentrations: - Nominal and measured concentrations:
- 2.0 (concentration level 1) and 0.2 ppm (concentration level 2)
- Remarks on result:
- other: not indicated
- Details on results:
- Recovery rate: 71.9 %
The accumulation rate resulted to be lower than ca 0.14 at the concentration level of 2 ppm (corresponding to the actual conc. of 1.7 ppm) and lower than 1.3 at the concentration level of 0.2 ppm. - Conclusions:
- The accumulation rate resulted to be lower than ca 0.14 at the concentration level of 2 ppm (corresponding to the actual conc. of 1.7 ppm) and lower than 1.3 at the concentration level of 0.2 ppm.
- Executive summary:
The bioaccumulative potential of test item was assessed in Japanese Killifish. The test item concentration was measured in water and in fish tissues, by HPLC method. Based on the TLm value determined in preliminary test, two concentration levels were chosen: 2.0 (concentration level 1) and 0.2 ppm (concentration level 2).
The accumulation rate resulted to be lower than ca 0.14 at the concentration level of 2 ppm (corresponding to the actual conc. of 1.7 ppm) and lower than 1.3 at the concentration level of 0.2 ppm.
Reference
Test results
Days | Accumulation rate at 2.0 ppm | Accumulation rate at 0.2 ppm | ||
3 | A | < 0.14 | A' | < 1.3 |
B | < 0.15 | B' | < 1.2 | |
7 | A | < 0.12 | A' | < 1.4 |
B | < 0.14 | B' | < 1.3 | |
14 | A | < 0.13 | A' | < 1.3 |
B | < 0.14 | B' | < 1.4 | |
21 | A | < 0.15 | A' | < 1.3 |
B | < 0.12 | B' | < 1.2 | |
28 | A | < 0.13 | A' | < 1.4 |
B | < 0.14 | B' | < 1.2 | |
42 | A | < 0.12 | A' | < 1.2 |
B | < 0.14 | B' | < 1.3 | |
56 | A | < 0.13 | A' | < 1.3 |
B | < 0.16 | B' | < 1.4 |
Actual measured concentration level
Conc. level | 1 w | 2 w | 3 w | 4 w | 6 w | 8 w |
At 2.0 ppm | 1.8 | 1.8 | 1.8 | 1.8 | 1.8 | 1.7 |
At 0.2 ppm | 0.19 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 |
Description of key information
No bioaccumulation potential expected.
Key value for chemical safety assessment
Additional information
The substance is expected to possess a low potential for bioaccumulation, based on the screening evaluation taken into account the experimental log Pow; on the basis of the molecular mass (i.e. greater than 700) and the steric hindrance, the possible passage of gill membranes or cell membranes of respiratory organs is expected to be negligible.
In addition, the bioaccumulative potential of test item was assessed in Japanese Killifish. The test item concentration was measured in water and in fish tissues, by HPLC method. The accumulation rate resulted to be lower than ca 0.14 at the concentration level of 2 ppm (corresponding to the actual conc. of 1.7 ppm) and lower than 1.3 at the concentration level of 0.2 ppm.
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