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EC number: 204-976-0 | CAS number: 130-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/ sediment:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical sodium naphthalene-1-sulfonate is non-bioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic/ sediment:
Various predicted data for the target compound sodium naphthalene-1 -sulfonate (CAS No. 130 -14 -3) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In first study BCF value of test chemical was estimated by using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical sodium naphthalene-1-sulfonate is non-bioaccumulative in food chain.
Next study was reviewed from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium naphthalene-1-sulfonate (CAS no. 130 -14 -3) was estimated to be 5.83 dimensionless. The predicted BCF result was based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium naphthalene-1-sulfonate is non-bioaccumulative in nature.
Another study was reviewed from authoritative database (J check, 2018) in this study the Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test substance under static conditions. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Test chemical nominal conc. used for the study were 10 mg/l and 1 mg/l (w/v). Range finding study involve the TLm (48 hr) ≥ 4000 mg/l on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be < 0.6 L/Kg at a conc. of 10 mg/l and < 6 L/Kg at a conc. of 1 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Further, to support above mentioned studies another study was reviewed from authoritative database (HSDB, 2017) in this study the bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of -0.14 and a regression derived equation. The BCF (bioaccumulation factor) value of test chemical was determined to be 0.5 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.
Last study was reviewed from authoritative database (J check, 2018) in this study Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 8 weeks for evaluating the bioconcentration factor (BCF value) of test substance under static conditions. Test chemical nominal conc. used for the study were 5 mg/l and 0.5 mg/l (w/v). Range finding study involve the TLm (48 hr) 610 mg/l on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be< 0.6 L/Kg at a conc. of 5 mg/l and < 6 L/Kg at a conc. of 0.5 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
On the basis of above results for target chemical sodium naphthalene-1-sulfonate (from, EPI suite, CompTox Chemistry Dashboard, 2017) and for its read across substance (from authoritative database HSDB and J-CHECK, 2017), it can be concluded that the BCF value of test substance sodium naphthalene-1-sulfonate was in range from 3.162 to 5.83 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical sodium naphthalene-1 -sulfonate is not expected to bioaccumulate in the food chain
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