Fatty acids, linseed-oil, reaction products with bisphenol A-epichlorohydrin polymer and glycidyl neodecanoate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From April 08, 2016 to April 15, 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

not specified

Type of method:

flask method

Remarks:

measurement of DOC concentration via TOC analyser

Specific details on test material used for the study:

Batch no.: #210162718
Composition: Reaction products of linseed-oil fatty acids, 4,4'-methylendiphenyldiglycidylether with neodecanoic fatty acid, oxiranylmethylester
Purity: 100 % as per definition of UVCB
(Based on the amount of CO2, the carbon content of the test substance was calculated to be 73.21 %.)

Key result

Water solubility:

22 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 006 mg/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

6.69

Key result

Water solubility:

47.8 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

3 000 mg/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

5.6

Key result

Water solubility:

79.7 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

6 006 mg/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

5.16

Key result

Water solubility:

95.8 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

8 002 mg/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

5.13

Key result

Water solubility:

112.7 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

10 000 mg/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

4.75

Details on results:

As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 1006 – 10000 mg/L was 22.0 – 112.7 mg/L at 20.0 ± 0.5 °C, corresponding to 1.1 – 2.2 % of the test substance relating to the nominal concentration of the test substance.

NB. All filtrated test solutions showed no Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid).

Conclusions:

Under the study conditions, the water solubility of the test substance was determined to be in the range of 22.0 to 112.7 mg/L for tested nominal concentrations going from 1006 to 10000 mg/L, at 20.0 ± 0.5 °C (Flask method).

Executive summary:

A study was conducted to determine the water solubility of the test substance according to OECD Guideline 105 and EU method A.6 (Flask method). The quantity of test substance necessary to saturate the desired volume of water was first determined in a preliminary test (with nominal concentrations of 10 mg/L and 1000 mg/L test substance). In the main test, six different loading rates of the test substance were chosen to study the effect of the loading rate on the measured water solubility: 1000, 3000, 5000, 6000, 8000 and 10000 mg/L (nominal). Measurements were realised after 24, 48 and 72h. The measurements after 72h were further selected for the calculation of the solubility of the test substance in water. As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. Under the study conditions, the solubility range for the tested nominal concentration 1006 – 10000 mg/L was 22.0 – 112.7 mg/L at 20.0 ± 0.5 °C, corresponding to 1.1 – 2.2 % of the test substance relating to the nominal concentration of the test substance (Affolter 2016).

Description of key information

The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Flask method) (Affolte, 2016).

Key value for chemical safety assessment

Water solubility:

112.7 mg/L

at the temperature of:

20 °C

Additional information

Water solubility was dependent on nominal concentration and ranged between 22.0 – 112.7 mg/L at 20.0 ± 0.5°C.