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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
Solutions of the test material were prepared at approximately 10 mg/l in the buffer solutions and maintained at 50°C for 5 days.The concentration of test material was monitored by gas chromatography as follows:
Samples
50 ml of each sample was extracted with three 15 ml portions of dichloromethane, each extract being filtered through anhydrous sodium sulphate. The combined extracts were then diluted to 50 ml using dichloromethane. This was performed in duplicate, (A and B), for the Initial, 2.4 hour, 24 hour and 120 hour samples
Standards
Standard solutions were prepared in dichloromethane at a nominal concentration of 10 mg/l.
Buffers:
SPECIFICATION OF BUFFER SOLUTIONS:
pH4
Citric acid 0.05 mol . dm-3
Sodium hydroxide 0.10 mol .dm-3
Hydrochloric acid 0.05 mol . dm-3pH7
Disodium hydrogen orthophosphate 0.04127 mol .dm-3
Potassium dihydrogen orthophosphate 0.0282 mol . dm-3

pH9
Disodium tetraborate 0.05 mol .dm-3
Hydrochloric acid 0.0192 mol .dm-3
Duration:
2.4 h
pH:
4
Temp.:
50 °C
Duration:
24 h
pH:
4
Temp.:
50 °C
Duration:
120 h
pH:
4
Temp.:
50 °C
Duration:
2.4 h
pH:
7
Temp.:
50 °C
Duration:
24 h
pH:
7
Temp.:
50 °C
Duration:
120 h
pH:
7
Temp.:
50 °C
Duration:
2.4 h
pH:
9
Temp.:
50 °C
Duration:
24 h
pH:
9
Temp.:
50 °C
Duration:
120 h
pH:
9
Temp.:
50 °C
Number of replicates:
Duplicates (A and B)
Positive controls:
no
Negative controls:
no
Statistical methods:
none
Preliminary study:
none
Transformation products:
not specified
% Recovery:
> 90
pH:
4
Temp.:
50 °C
Duration:
5 d
Remarks on result:
not determinable
% Recovery:
> 90
pH:
7
Temp.:
50 °C
Duration:
5 d
Remarks on result:
not determinable
% Recovery:
> 90
pH:
9
Temp.:
50 °C
Duration:
5 d
Remarks on result:
not determinable
Key result
Remarks on result:
not measured/tested
Details on results:
See enclosed pdf document
Validity criteria fulfilled:
yes
Conclusions:
ET-344 SP was found to undergo less than 10% hydrolysis after 5 days at 50°C in pH 4, 7 and 9 buffer solutions.
Executive summary:

EU method C.7 was followed

Solutions of the test material were prepared at approximately 10 mg/l in the buffer solutions and maintained at 50°C for 5 days

The concentration of test material was monitored by gas chromatography

ET-344 SP was found to undergo less than 10% hydrolysis after 5 days at 50°C in pH 4, 7 and 9 buffer solutions.

Description of key information

EU method C.7 was followed

Solutions of the test material were prepared at approximately 10 mg/l in the buffer solutions and maintained at 50°C for 5 days

The concentration of test material was monitored by gas chromatography

ET-344 SP was found to undergo less than 10% hydrolysis after 5 days at 50°C in pH 4, 7 and 9 buffer solutions.

Key value for chemical safety assessment

Additional information