2-hydroxy-3-(prop-2-enoyloxy)propyl 2-methyl-2-propylhexanoate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

other justification

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

not specified

Type of method:

effusion method: Knudsen cell

Specific details on test material used for the study:

Batch no.: lot # JBGJ0045R
Purity: 100% (UVCB)

Key result

Temp.:

20 °C

Vapour pressure:

0.01 Pa

Remarks on result:

other: calculated from the regression equation

Key result

Temp.:

25 °C

Vapour pressure:

0.012 Pa

Remarks on result:

other: calculated from the regression equation

Key result

Temp.:

45 °C

Vapour pressure:

0.028 Pa

Key result

Temp.:

60 °C

Vapour pressure:

0.047 Pa

Key result

Temp.:

75 °C

Vapour pressure:

0.077 Pa

Table 1. Measured values for temperature and vapour pressure        

Temperature (°C)	Vapour pressure (Pa)	Standart deviation (Pa)
45	2.77E-02	1.97E-03
60	4.67E-02	2.60E-03
75	7.71E-02	1.11E-02

For the test substance, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

20°C: 1.00E-02 Pa

25°C: 1.24E-02 Pa

The linear regression of log p vs. 1/T gave a correlation coefficient r of - 0.9999, showing good repeatability and precision. Therefore, the determination is considered as valid.

Conclusions:

Under the study conditions, the vapour pressures of the test substance were dextrapolated using regression line and were determined to be 1.00E-02 and 1.24E-02 Pa at 20 and 25°C, respectively (Knudsen cell).

Executive summary:

A study was conducted to determine the vapour pressure of the test substance according to OECD Guideline 104 and EU Method A.4 (Knudsen cell). The vapour pressure of the test substance was determined by the Knudsen cell effusion method. The test substance was weighed into the 4 Knudsen cells, which were set into vacuum chamber at 10E-05 Pa or lower followed by measurements at 30, 45, 60 and 75°C. The measurement at 30°C showed no significant weight loss. Therefore, this experiment was not included in the evaluation. The measured values for temperature and vapour pressure were evaluated as follows: 2.77E-02, 4.67E-02 and 7.71E-02 at 45, 60 and 75°C, respectively. Under the study conditions, the vapour pressures of the test substance were extrapolated using regression line and were determined to be 1.00E-02 and 1.24E-02 Pa at 20 and 25°C, respectively (Henke, 2015).

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

appearance / physical state / colour

Type of information:

other: assessed from other experimental study report

Adequacy of study:

key study

Study period:

2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: assessed from other experimental study report

Principles of method if other than guideline:

Information assessed from the biodegradation study report

GLP compliance:

yes

Specific details on test material used for the study:

Batch no.: JBGJ0045R
Purity: 100% (UVCB)

Physical state at 20°C and 1013 hPa:

liquid

Key result

Form:

liquid

Colour:

clear yellowish

Substance type:

organic

Conclusions:

The test substance was identified as a clear yellowish liquid.

Executive summary:

The test substance was identified as a clear yellowish liquid (Muckle, 2016).