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EC number: 203-640-0 | CAS number: 109-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across GLP study performed according to OECD Guideline 211. An English summary is available from the Japanese authorities and an extensive summary is present in the OECD HPV program files.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-ethylmorpholine
- Molecular formula (if other than submission substance): C6H13NO
- Molecular weight (if other than submission substance): 115.18
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state:
- Analytical purity: 99.9%
- Lot/batch No.: SEG4563
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material:
- Other: - Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: crustacea
- Justification for species other than prescribed by test guideline:
- Source:
- Age of parental stock (mean and range, SD): < 24 hours old
- Feeding during test: no
- Food type:
- Amount:
- Frequency:
ACCLIMATION
- Acclimation period: 4 weeks
- Acclimation conditions (same as test or not):
- Type and amount of food: Chlorella vulgaris
- Feeding frequency: 0.2 mg carbon/day/individual
- Health during acclimation (any mortality observed): mortality was less than 5% for 2 weeks before testing
QUARANTINE (wild caught)
- Duration:
- Health/mortality:
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Hardness:
- 250 - 270 mg/L
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.5 - 8.8
- Dissolved oxygen:
- 7.5 - 8.9 mg/L
- Nominal and measured concentrations:
- Nominal Concentrations: control and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 80 mL test solution in a 100 mL glass beaker covered water surface with teflon sheet and capped.
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume:
- Aeration: none
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates):
- No. of vessels per vehicle control (replicates):
- Biomass loading rate:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
- Total organic carbon:
- Particulate matter:
- Metals:
- Pesticides:
- Chlorine:
- Alkalinity:
- Ca/mg ratio:
- Conductivity:
- Salinity:
- Culture medium different from test medium:
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH: pH on the concentration, 100mg/L (7.5 - 8.4) were higher than pH on the control (8.6 - 8.8). It was considered to be caused by test substance. pH of the test solutions were not adjusted during test period.
- Photoperiod:
- Light intensity: 16:8 hours, light-darkness cycle
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
VEHICLE CONTROL PERFORMED: yes/no
RANGE-FINDING STUDY
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Mortality of parent animals: 0% at 100 mg/L
- No. of offspring produced per day per female:
- Body length and weight of parent animals:
- Type and number of morphological abnormalities:
- Type and number of behavioural abnormalities:
- Number of males and females (parental)
- Time to first brood release or time to hatch: All parental daphnids (both control and concentration, 100 mg/L) had first brood after 8 days.
- Egg development time
- Brood size
- Time to sexual maturity
- Type and magnitude of biochemical changes
- Other biological observations:
- Effect concentrations exceeding solubility of substance in test medium: - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: 48 h EC50 = 0.75 mg/L
- Other: - Conclusions:
- The long-term toxicity of 4-ethylmorpholine to aquatic invertebrates was assessed in an OECD 211 study with Daphnia magna. The following effect values resulted based on the reproduction: NOEC (21 d) = 100 mg/L (MOE, Japan, 2003).
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- read across from related substance
- Justification for type of information:
- Read-across from structural analogue (4-ethylmorpholine). Justification of this read-across approach is included in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Conclusions:
- No reliable data for this endpoint with the target substance is available. Data generated with the related substance 4-ethylmorpholine is used for endpoint coverage. The long-term toxicity of 4-ethylmorpholine to aquatic invertebrates was assessed in an OECD 211 study with Daphnia magna. The following effect values resulted based on the reproduction: NOEC (21d) = 100 mg/L (MOE, Japan, 2003). The same is assumed to be correct for the target substance.
Referenceopen allclose all
Description of key information
Following the read-across strategy, it is considered appropriate to cover this endpoint by a key study performed with the structural analogue 4-ethyl morpholine, yielding a NOEC value of 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The long-term toxicity of the structural analogue 4-ethylmorpholine to aquatic invertebrates was assessed in an OECD 211 study with Daphnia magna. The following effect values resulted based on the reproduction: NOEC (21 d) = 100 mg/L (MOE, Japan, 2003). The justification for read-across within this endpoint can be found in section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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