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EC number: 249-482-6 | CAS number: 29171-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978, other details not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: pre-GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38, No. 187, 5 .1500.42, S. 27019 dated 27.09.73
- Principles of method if other than guideline:
- Assessment according to Draize
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- EC Number:
- 249-482-6
- EC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Cas Number:
- 29171-20-8
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Reference substance name:
- 29717-20-8
- IUPAC Name:
- 29717-20-8
- Details on test material:
- - Name of test material (as cited in study report): Dehydrolinalool
- Physical state: liquid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: non treated eye
- Amount / concentration applied:
- not known
- Observation period (in vivo):
- Observations of the eyes were made 24, 48, 72 h, and 8 days later.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The test substance (amount not indicated) was instilled into the conjunctival say of one eye of six rabbits. Observations of the eyes were made 24, 48, 72 h, and 8 days later. Parameters evaluated were corneal opacity and area involved, iris as well as conjunctiva redness, chemosis, and secretion. Scoring of the eyes was done as follows: For cornea and conjunctiva chemosis grade 1 ¿ mild, grade 2 - marked, grade 3 ¿ strong and grade 4 ¿ very strong were used. For conjunctiva redness and secretion grade 1 - mild, grade 2 - marked, and grade 3 - strong were used. For iris grade 1 ¿ ciliary injection, and grade 2 ¿ iritis were used.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- iris score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- other: secretion
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 d
- Irritant / corrosive response data:
- Corneal opacity grade 1 was noted in all 6 animals at the 24, 48 h reading getting to grade 2 corneal opacity in 4 out of 6 animals after 72 h. After 8 days grade 1 (3 animals) and grade 2 (3 animals) were noted. The involved area was more than 75% of the cornea. Ciliary injection was noted in 3 of 6, 5 of 6, 5 of 6 and 1 of 6 animals after 24, 48, 72h, and 8 days, respectively. Conjunctiva scores were noted in 2 of 6 (24h reading), 5 of 6 (48 and 72 h reading) and 4 of 6 animals (8 days reading). Grade 1-2 conjunctiva redness was seen in all animals up to day 8, grade 2 chemosis was seen after 24h with tendency to regression in all animals. After 8 days, grade 1 chemosis was seen only in 2 animals. Grade 1 secretion was noted in 5 of 6 animals with 1 animal showing grade 3 secretion at 24, 48, and 72 h. After 8 days, all animals showed grade 1 secretion.
- Other effects:
- no remarks
Any other information on results incl. tables
Eye Irritation: Scores after 24, 48, and 72 h for the undiluted test item
|
|
Time after instillation* |
|
|||
|
Animal No |
24h |
48h |
72h |
8 days |
Mean (24-72 hours) |
Corneal |
1 |
1 (4) |
1 (4) |
2 (4) |
1 (4) |
1.3 |
opacity |
2 |
1 (4) |
1 (4) |
2 (4) |
1 (4) |
1.3 |
|
3 |
1 (4) |
2 (4) |
2 (4) |
2 (4) |
1.7 |
|
4 |
1 (4) |
1 (4) |
1 (4) |
2 (4) |
1.0 |
|
5 |
1 (4) Pv |
1 (4) Pv |
1 (4) Pv |
1 (4) |
1.0 |
|
6 |
1 (4) |
1 (4) |
2 (4) |
2 (4) Pv |
1.3 |
Iris |
1 |
0 |
0 |
1 |
0 |
0.3 |
|
2 |
1 |
1 |
0 |
0 |
0.7 |
|
3 |
0 |
1 |
1 |
0 |
0.7 |
|
4 |
0 |
1 |
1 |
0 |
0.7 |
|
5 |
1 |
1 |
1 |
0 |
1.0 |
|
6 |
1 |
1 |
1 |
1 |
1.0 |
Conjunctiva |
|
|
|
|
|
|
redness |
1 |
1 |
1 |
1 |
1 |
1.0 |
|
2 |
2 |
2 Na |
2 Na |
1 |
2.0 |
|
3 |
2 Na |
2 Na |
2 Na |
2 Na |
2.0 |
|
4 |
2 |
2 Na |
2 Na |
1 Na |
2.0 |
|
5 |
2 Na |
2 Na |
2 Na |
1 Na |
2.0 |
|
6 |
2 |
2 Na |
2 Na |
2 Na |
2.0 |
chemosis |
1 |
2 |
0 |
0 |
0 |
0.7 |
|
2 |
2 |
2 |
1 |
0 |
1.7 |
|
3 |
2 |
2 |
2 |
1 |
2.0 |
|
4 |
2 |
2 |
1 |
0 |
1.7 |
|
5 |
2 |
1 |
1 |
0 |
1.3 |
|
6 |
2 |
1 |
1 |
1 |
1.3 |
secretion |
1 |
1 |
1 |
1 |
1 |
1.0 |
|
2 |
1 |
1 |
1 |
1 |
1.0 |
|
3 |
3 |
3 |
3 |
1 |
3.0 |
|
4 |
1 |
1 |
1 |
1 |
1.0 |
|
5 |
1 |
1 |
1 |
1 |
1.0 |
|
6 |
1 |
1 |
1 |
1 |
1.0 |
* values
in brackets indicate area involved (4 = > ¾)
Pv pupil
constricted
Na Scar
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the criteria laid down in Regulation 1272/2008/EC, the test item is considered an eye irritant (category 2).
- Executive summary:
Based on the criteria laid down in Regulation 1272/2008/EC, the test item is considered an eye irritant (category 2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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