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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other: no indication
Principles of method if other than guideline:
no remarks
GLP compliance:
no
Remarks:
pre-GLP
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyloct-6-en-1-yn-3-ol
EC Number:
249-482-6
EC Name:
3,7-dimethyloct-6-en-1-yn-3-ol
Cas Number:
29171-20-8
Molecular formula:
C10H16O
IUPAC Name:
3,7-dimethyloct-6-en-1-yn-3-ol
Constituent 2
Reference substance name:
29717-20-8
IUPAC Name:
29717-20-8
Details on test material:
- Name of test material (as cited in study report): 77-123, DHL, Dehydro Linalool

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Sex not specified; however since observations on "blood on penis" are reported, some of the test animals were for sure males.

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Ten rabbits (age not specified) received dermally a dose of 5 g /kg bw.
Duration of exposure:
Not known. Animals were observed for at least 5 days.
Doses:
5 g /kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
no remarks
Statistics:
no remarks

Results and discussion

Preliminary study:
no remarks
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Three animals died on days 1, 2, and 5 with day 0 being the day of application.
Clinical signs:
The clinical signs were ataxia, dyspnea, lethargy, yellow discharge from nose, ptosis, and dacryorrhea. Skin irritation was noted and consisted of severe redness (9 of 10 animals) and moderate edema (8 of 10 animals) and severe edema (1 animal).
Body weight:
No data
Gross pathology:
All animals were necropsied. Necropsy observations of the animals that died revealed lungs with dark areas, dark and mottled liver, mottled kidney with white areas; intestines blotted or with hard matter; stomach with dark green areas and enlarged spleen.
Other findings:
no remarks

Any other information on results incl. tables

Not relevant

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 in rabbits was calculated to be greater than 5000 mg/kg bw.
Executive summary:

The dermal LD50 in rabbits was calculated to be greater than 5000 mg/kg bw.