Registration Dossier
Registration Dossier
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EC number: 203-552-2 | CAS number: 108-12-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound isovaleryl chloride: No data available.
Hydrolysis product isovaleric acid: No data available.
There are no experimental data available for the parent compound and its hydrolysis product, therefore the short-term toxicity to fish is assessed on the results of the structurally similar substance valeryl chloride and its hydrolysis product valeric acid.
Valeryl chloride: With high probability acutely not harmful to fish (after pH-adjustment).
Valeric acid: Acutely harmful to fish.
Hydrolysis product HCl: Acutely toxic for fish (pH-dependent).
Key value for chemical safety assessment
Additional information
Isovaleryl chloride (CAS 108-12-3) rapidly decomposes in water and forms HCl (CAS 7647-01-0) and isovaleric acid (CAS 503-74-2). Since there are neither experimental data available for isovaleryl chloride nor for its hydrolysis product isovaleric acid, short-term toxicity to fish is assessed via read across to the structurally similar substances isobutyryl chloride (CAS 79-30-1), isobutyric acid (CAS 79-31-2), valeryl chloride (CAS 638-29-9) and valeric acid (CAS 109-52-4).
Isobutyryl chloride and isobutyric acid:
The toxicity of isobutyryl chloride to the test organism Danio rerio was tested according to OECD 203 (Fish, acute Toxicity Test). The 96-h LC50 was determined to be 280.7 mg/L (measured, not neutralized; BASF, 1999; report no. 17F0505/965151).
The toxicity of isobutyric acid to Leuciscus idus was tested according to German Industrial Standard DIN 38412, part 15. No analytical monitoring was performed. The 96-h LC50 was determined to be 146.6 mg/L (nominal; not neutralised; BASF, 1989; report no. 10F0167/89107).
Valeryl chloride and valeric acid:
The acute fish toxicity of valeryl chloride (638 -29 -9) was determined withLeuciscus idusaccording to the German Industrial Standard DIN 38412, L15. The obtainedLC50 (96 h) was 68.1 mg/L. When tested under neutralised conditions (pH-adjustment), the LC50 was > 100 mg/L (BASF, 1987;report no.10F0207/875168).
The acute fish toxicity of valeric acid (CAS 109 -52 -4) to the test organism Pimephales promelas was studied in two acute toxicity tests according to guidelines of the American Public Health Association, 1971 (Standard methods for the Examination of Water and Wastewater). The obtained 96 -h LC50 values were 77 mg/L and 39 mg/L, respectively (geometric mean LC50 = 54.8 mg/L; Mattson et al. 1976; ECHA, 2011).
Based on the available data, isovaleryl chloride is assessed to be with high probability acutely not harmful to fish (after pH-adjustment). The hydrolysis product isovaleric acid is acutely harmful to fish.
Hydrolysis product hydrochloric acid (HCl):
HCl was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96-h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD, 2002).
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