Registration Dossier
Registration Dossier
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EC number: 231-198-9 | CAS number: 7446-14-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: acute
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Sixteen Holstein intact male calves averaging 85 kg and 74 days of age were assigned randomly to four dietary lead treatments according to body weight.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead sulphate
- EC Number:
- 231-198-9
- EC Name:
- Lead sulphate
- Cas Number:
- 7446-14-2
- Molecular formula:
- H2O4S.Pb
Constituent 1
Test animals
- Species:
- cattle
- Strain:
- other: Holstein Calf
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7-wk experimental period
- Frequency of treatment:
- Twice a day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500, 1500, or 4500 ppm Pb as lead sulfate
Basis:
nominal in diet
- No. of animals per sex per dose:
- 4, randomly assigned
- Control animals:
- yes, plain diet
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There was a linear increase of lead in blood with time on treatment for calves receiving the 500 ppm Pb diet.
Lead in blood of the two calves receiving 1500 ppm added Pb appeared to peak at 4 wk, then remained about the same until the 6th wk. All calves receiving 4500 ppm supplemental lead died within 10 days from onset of the experiment.
From our research and also from review of published data, cattle vary considerably in degrees of toxicity resulting from consuming different amounts of lead from various sources. Differences of published reports may be due to the many variables that may include different chemical forms.
Applicant's summary and conclusion
- Conclusions:
- Lead sulfate, which is one of the more common environmental pollutants, apparently is less toxic to cattle than some forms that have been studied more.
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