Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2002

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
dermal absorption
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The objective of this study was to determine percutaneous absorption of lead compounds, including lead sulfate. The lead content on the skin surface of 10 lead-battery workers was measured by the method of skin stripping.
GLP compliance:
not specified

Method

Subjects:
- Number of subjects exposed: 10
- Sex: males
- Other: Lead battery workers
Route of exposure:
dermal
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Clinical signs:
The total amount of lead obtained in the 10 strips of the dorsal hand ranged from 20.74 to 86.53 µg, and of the low back ranged from 8.94 to 28.32 µg. The total amount of lead dorsal hand was linearly correlated with the amount in blood (n=10, r²=0.6586, p<0.05, linear regression, figure 2b). There was a decreasing amount of lead content in the exposed skin going from the outer to the inner layers.

Applicant's summary and conclusion

Conclusions:
In the conditions of the study, we cannot conclude about the absorption of lead sulfate in human.