Registration Dossier

Administrative data

Endpoint:
specific investigations: behavioural effects
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
basic toxicokinetics

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
cattle
Strain:
other: Holstein calf
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 weeks
Frequency of treatment:
Twice daily
Doses / concentrations
Remarks:
Doses / Concentrations:
1000 ppm
Basis:
nominal in diet
No. of animals per sex per dose:
6
Control animals:
yes, plain diet

Results and discussion

Details on results:
Supplementation PbSO4 caused a decrease in all parameters used to study Se metabolism, e.g., absorption, tissue distribution, and endogenous excretion of Se. Absorption was decreased 26% and urinary excretion by 42%. The greater effect on excretion than on absorption indicated that Pb has an effect on Se metabolism after absorption.

Applicant's summary and conclusion

Conclusions:
In this study, Lead sulphate was found to interact with Selenium, inducing a low er toxicity. Yet, mechanism is unknown.