Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-537-0 | CAS number: 107-96-0
Categories
- Category name:
- 3-MPA family, simple esters
Justifications and discussions
- Category definition:
- 3-Mercaptopropionic acid, and its esters
- Category description:
- This category includes 3-MPA and esters of 3-MPA with mono-alcohols differing in C-chain length (C1 – C18) and degree of branching.
- Category rationale:
- This category includes 3-MPA and esters of 3-MPA with mono-alcohols differing in C-chain length (C1 – C18) and degree of branching. BuMP and ODMP contain a linear alcohol side chain, whereas EHMP is manufactured from 2-ethylhexanol, and iOMP and iC13MP contain branched site chains with overall a low degree of branching (mostly methyl-branches).
3-MPA as free acid is included in this category, since it is formed by ester hydrolysis and is therefore the primary common metabolite in this category.
The category members follow structurally related trends in physical chemical properties (water solubility, log Kow, and vapour pressure). The available acute oral toxicity studies also revealed a trend towards less toxicity with increasing carbon chain length. All members share a common chemical reactivity, metabolism pathways and biological properties that enable interpolation and read across between category members for systemic toxicity endpoints.
Esters with poly-alcohols are assigned to a separate category since they contain more than one free sulfhydryl function.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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