Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-222-8 | CAS number: 6440-58-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
- EC Number:
- 229-222-8
- EC Name:
- 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
- Cas Number:
- 6440-58-0
- Molecular formula:
- C7H12N2O4
- IUPAC Name:
- 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
- Details on test material:
- The substance was tested as a 54.4% solution in water
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 500, 2320, 3410 and 5000mg/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 890 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 500 mg/kg - 0/10
At 2320 mg/kg - 1/10
At 3410 mg/kg - 8/10
At 5000 mg/kg - 9/10 - Clinical signs:
- other: Clinical changes noted during the observation period included ataxia, saliva and fecal stains, piloerection, shallow and gasping breathing, slight to severe depression, reddish stains around the eyes and on muzzle and dirty hair coats.
- Gross pathology:
- The gross necropsy findings in the animals that died were those generally seen in agonal animals. In the animals which survived there were no gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (rat, oral) for Glycoserve II - 2890mg/kg
- Executive summary:
The LD50 (rat, oral) for Glycoserve II = 2890mg/kg, equivalent to LD50 (rat; oral) for DMDMH - 1572mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
