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EC number: 229-222-8
CAS number: 6440-58-0
Waiver. In accordance with Regulation (EC) No 1907/2006 Annex IX section 188.8.131.52 and 184.108.40.206 column 2, a water and sediment simulation testing study is not required as the substance is readily biodegradable.
In accordance with Regulation (EC) No 1907/2006 Annex IX section 220.127.116.11
and 18.104.22.168 column 2, a water and sediment simulation testing study is
not required as the substance is readily biodegradable. Due to the rapid
hydrolysis of DMDMH, the degradation product DMH was considered for
environmental fate studies as this is the substance which would be
released into the environment. A ready biodegradability test has been
performed with DMH which shows 87% biodegradability passing the 10
day-window criterion; therefore there is no requirement for an aerobic
degradation study in soil.
information, there are no reliable water and sediment simulation studies
for DMDMH, however, there is a reliable sediment/water degradation study
available for the hydrolysis product, DMH. Due
to the rapid hydrolysis of DMDMH to DMH studies conducted with the
hydrolysis product, DMH, are considered relevant for environmental fate
and ecotoxicology and are considered in this dossier.
Vette and Schoonmade (2002) conducted reliable (Klimisch 1) GLP
compliant study following OECD 308 methods. Test results showed that DMH
was steadily degraded with whole systems and aqueous phase DT50 values
of 13 to 24 days which indicates that DMH is not persistent in
freshwater environments. The predominant degradation product was CO2which
accounted for 55 to 65% of the applied radioactivity at the end of the
incubation phase (17 weeks).
can be concluded that water and sediment simulation testing is not
required as the test substance and its degradation product are readily
biodegradable and not persistent in freshwater environments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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