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EC number: 229-222-8
CAS number: 6440-58-0
Four experiments were conducted as part of the study which involved the determination of the absorption, distribution, metabolism and excretion (ADME) patterns of 14C-5,5-dimethylhydantoin. The dosing regimens were as follows: A single oral low-dose(100mg/kg); a single oral high- dose(1000mg.kg); repeated oral low- dose (100mg/kg/day of non-radiolabelled DMH for days 1-7 and80mg/kg/day for days 8-14 followed by a single dose of 14C-DMH); A single I.V low-dose (100mg/kg)
DMDMH readily undergoes hydrolysis to form DMH. The available data
demonstrates that DMH is well absorbed and rapidly and quantitatively
excreted, unchanged, in the urine following oral or intravenous
administration. There was no evidence for significant tissue
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