Registration Dossier
Registration Dossier
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EC number: 278-934-5 | CAS number: 78521-39-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- other: HPLC method
- Water solubility:
- 317 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: bidistillated water
- Water solubility:
- 389 mg/L
- Temp.:
- 30 °C
- Remarks on result:
- other: bidistillated water
- Water solubility:
- 585 mg/L
- Temp.:
- 35 °C
- Remarks on result:
- other: bidistillated water
- Water solubility:
- ca. 13 g/L
- Remarks on result:
- other: Sörensen buffer (pH = 8.2)
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The water solubility was determined in a test according to OECD 105 to be 317 mg/L at 25°C. In Soerensen buffer (pH 8) the solubility increased drastically to 13 g/L at 20°C.
Reference
Description of key information
The water solubility was determined in a test according to OECD 105 to be 317 mg/L at 25°C. In Soerensen buffer (pH 8) the solubility increased drastically to 13 g/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 317 mg/L
- at the temperature of:
- 25 °C
Additional information
The strong dependency of the solubility from pH can be explained by the molecular structure. The carboxyl group dissociate at neutral or alkaline pH values which leads to a high solubility, in contrast to acidic pH values where the carboxyl groups are not dissociated.
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