Registration Dossier
Registration Dossier
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EC number: 204-688-5 | CAS number: 124-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the target substance and 2 source substances have the same expected mode of action and similar physicochemical properties relevant for the read-across endpoints.
The justification of the proposed read-across to 2,6-dimethyl-5-heptenal and heptanoic acid is discussed in the following chapters.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The target substance nonanal is a mono-constituent substance (EC 204-688-5, CAS 124-19-6). The typical concentration of the single constituent is 99.95%.
The source substance 2,6-dimethyl-5-heptenal (EC 203-427-2, CAS 106-72-9) is a mono-constituent substance. The typical concentration of the mono-constituents is 97.0%.
The source substance heptanoic acid (EC 203-838-7, CAS 111-14-8) is a mono-constituent substance. The typical concentration of the mono-constituents is 98.5%.
The chemical structure for the source substances is shown in Table 1 (RAAF Document) and the structural similarities for the source substances to undec-10-enal are given in Table 4 (RAAF Document).
The target substance and the source substances do not contain any impurities present at ≥ 1%. The purity of the test items within the respective REACH registration dossiers for 2-methylundecanal and heptanoic acid is > 99.00% and the data from the supplier Oxea Chemicals Ltd. for 2,6-dimethyl-5-heptenal indicates purity > 97.0% with no impurities > 1%.
3. ANALOGUE APPROACH JUSTIFICATION
The structures of the target and source substances are provided in Table 1. The target substance and the source substance have been characterised in this table using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling provided (Table 2), it can be seen that the 2 substances share structural similarities and also mechanistic actions which are both general and endpoint specific. This supports the hypothesis that the target and source substances have similar properties as a result of structural similarity and the same expected mode of action.
The OECD toolbox predicts all substances to be of low toxicity according to Cramer classes and both substances show no alerts according to DART Scheme v1.0.
Aldehyde C9 (nonanal) and 2,6-Dimethyl-5-heptenal are structurally similar aldehydes with a methyl substitution at the 2-position which is expected to be the primary site of metabolism. The primary route of metabolism for both substances is expected to be via rapid initial oxidation of the aldehyde function followed by glycine conjugation. This is supported by the most probable route of metabolism prediction of TIMES v.2.27.17 (rat in vivo model) as illustrated below.
4. DATA MATRIX
Please see the attached RAAF document.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Screening test
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets generally accepted scientific standards with acceptable restrictions for the standard test.
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the target substance and 2 source substances have the same expected mode of action and similar physicochemical properties relevant for the read-across endpoints.
The justification of the proposed read-across to 2,6-dimethyl-5-heptenal and heptanoic acid is discussed in the following chapters.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The target substance nonanal is a mono-constituent substance (EC 204-688-5, CAS 124-19-6). The typical concentration of the single constituent is 99.95%.
The source substance 2,6-dimethyl-5-heptenal (EC 203-427-2, CAS 106-72-9) is a mono-constituent substance. The typical concentration of the mono-constituents is 97.0%.
The source substance heptanoic acid (EC 203-838-7, CAS 111-14-8) is a mono-constituent substance. The typical concentration of the mono-constituents is 98.5%.
The target substance and the source substances do not contain any impurities present at ≥ 1%. The purity of the test items within the respective REACH registration dossiers for 2-methylundecanal and heptanoic acid is > 99.00% and the data from the supplier Oxea Chemicals Ltd. for 2,6-dimethyl-5-heptenal indicates purity > 97.0% with no impurities > 1%.
3. ANALOGUE APPROACH JUSTIFICATION
The structures of the target and source substances are provided in the RAAF document. The target substance and the source substance have been characterised in this table using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling provided (Table 2), it can be seen that the 2 substances share structural similarities and also mechanistic actions which are both general and endpoint specific. This supports the hypothesis that the target and source substances have similar properties as a result of structural similarity and the same expected mode of action.
The OECD toolbox predicts all substances to be of low toxicity according to Cramer classes and both substances show no alerts according to DART Scheme v1.0.
Aldehyde C9 (nonanal) and 2,6-Dimethyl-5-heptenal are structurally similar aldehydes with a methyl substitution at the 2-position which is expected to be the primary site of metabolism. The primary route of metabolism for both substances is expected to be via rapid initial oxidation of the aldehyde function followed by glycine conjugation. This is supported by the most probable route of metabolism prediction of TIMES v.2.27.17 (rat in vivo model) as illustrated below. - Qualifier:
- according to guideline
- Guideline:
- other: Unclear; makes reference to FDA (1987)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum):No data
- Water (e.g. ad libitum):No data
- Acclimation period:No data
- Other: Nulliparous
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): No data
- Mixing appropriate amounts with (Type of food):No data
- Storage temperature of food: No data
VEHICLE
- Justification for use and choice of vehicle: No data
- Concentration in vehicle: No data
- Amount of vehicle: 5 mL/kg bw/d - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1 week treatment followed by 7 d cohabitation period through gestation, parturition and 4-d postpartum period.
- Frequency of treatment:
- Daily
- Remarks:
- Doses / Concentrations:
300 mg/kg bw/d
Basis:
no data - Remarks:
- Doses / Concentrations:
1500 mg/kg bw/d
Basis:
no data - Remarks:
- Doses / Concentrations:
3000 mg/kg bw/d
Basis:
no data - No. of animals per sex per dose:
- 10 females per dose
- Control animals:
- yes, concurrent vehicle
- Parental animals: Observations and examinations:
- CAGE-SIDE OBSERVATIONS
- Viability was monitored twice daily during the study.
- Rats were observed daily for clinical signs approx. 30 mins after gavage administration.
BODY WEIGHT
- Measurement of body weight was performed weekly.
FOOD CONSUMPTION
- Food consumption measurement was also conducted weekly during the premating/premating period and then on days 0, 6, 14, 16, 21, and 25 of gestation and on days 1 and 4 of lactation/postparturition.
MATING PERFORMANCE
- Mating performance was evaluated daily during the cohabitation period.
- Dams were evaluated daily during gestation for duration of gestation, maternal behaviour, litter size and pup viability. - Oestrous cyclicity (parental animals):
- Mating, day 0 of gestation identified on basis of spermatozoa in vaginal smear.
- Postmortem examinations (parental animals):
- SACRIFICE
- Dams that did not deliver litters were sacrificed on day 25 of presumed gestation and dams that did deliver litters were sacrificed on days 4 or 5 of lactation. All dams were examined for gross lesions and implantation sites.
GROSS NECROPSY
- Ovaries from all dams and any observed gross lesions were preserved in neutral 10% formalin for possible evaluation. - Postmortem examinations (offspring):
- GROSS NECROPSY
- Vital signs at birth were determined for pups that were stillborn or died before the initial examination of the litter.
- Each litter was evaluated for viability a minimum of twice daily during the 4-day lactation period.
- Dead pups were removed and necropsied.
- Tissues with gross lesions were preserved for possible examination.
- Pups in each litter were counted and observed for nursing behaviour and physical abnormalities daily.
- Pup body weights were measured on days 1 and 4 of postpurition. - Statistics:
- Fisher's ANOVA followed by Dunnett's test
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- not examined
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 1 500 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation (if dermal study):
- no effects observed
- Mortality / viability:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings:
- not examined
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Key result
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 1 500 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- Key result
- Reproductive effects observed:
- no
- Lowest effective dose / conc.:
- 300 mg/kg bw/day
- Treatment related:
- no
- Conclusions:
- The test substance was assessed for toxicity to reproduction using a one-generation study in rats. The results showed that under the conditions of the test, dose levels of 300 mg/kg bw/day of the test material (5-heptenal, 2,6-dimethyl) had no adverse effects on the reproductive performance of female Sprague-Dawley rats or the growth or development of their offspring.
- Clinical signs at 1500 and 3000 mg/kg in dams included decreased activity and excess salivation during the pregestation
period and increased (P<0.01) salivation in the high dose group during gestation.
BODY WEIGHT
- Significant (P<0.05 to <0.01) decreases in body weight and absolute and relative food consumption were measured during the premating period.
- Maternal body weights were decreased during gestation for the mid- and highdose groups of dams.
- Decreased body weights and absolute and relative food consumption in the 300 mg/kg bw/day group occurred only during premating and were not considered adverse effects.
MORTALITY
- 8/10 rats in the high dose group were moribund or found dead on days 2, 3,and 4 of the premating period.
- 1/2 surviving high-dose dams delivered a litter that died during the 4-day lactation period.
MATING AND FERTILITY
-Mating and fertility at the high dose were similar to controls.
-Measurements of mating success and fertility were similar for controls, low- and mid-dose groups.
- Significant (P<0.05 to <0.01) decreases in pup viability occurred for middle and high dose groups as compared to controls.
NUMBER OF OFFSPRING
- The mid-dose litters were significantly less (P<0.05) than control group litters (sic).
BODY WEIGHT
- High-dose litters weighed remarkably less than controls.
OTHER
- No changes in averages for duration of cohabitation or gestation, implantation sites or pup sex ratios were seen at any dose levels.
GROSS PATHOLOGY
- No malformations or gross lesions in pups were attributable to the test material.
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- one-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- It is a GLP compliant study conducted in compliance with agreed protocols, with no or minor deviations for the standard test.
- Qualifier:
- according to guideline
- Guideline:
- other: Unclear; makes reference to FDA (1987)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum):No data
- Water (e.g. ad libitum):No data
- Acclimation period:No data
- Other: Nulliparous
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): No data
- Mixing appropriate amounts with (Type of food):No data
- Storage temperature of food: No data
VEHICLE
- Justification for use and choice of vehicle: No data
- Concentration in vehicle: No data
- Amount of vehicle: 5 mL/kg bw/d - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1 week treatment followed by 7 d cohabitation period through gestation, parturition and 4-d postpartum period.
- Frequency of treatment:
- Daily
- Dose / conc.:
- 200 mg/kg bw/day
- Dose / conc.:
- 1 000 mg/kg bw/day
- Dose / conc.:
- 2 000 mg/kg bw/day
- No. of animals per sex per dose:
- 10 females per dose
- Control animals:
- yes, concurrent vehicle
- Parental animals: Observations and examinations:
- CAGE-SIDE OBSERVATIONS
- Viability was monitored twice daily during the study.
- Rats were observed daily for clinical signs approx. 30 mins after gavage administration.
BODY WEIGHT
- Measurement of body weight was performed weekly.
FOOD CONSUMPTION
- Food consumption measurement was also conducted weekly during the premating/premating period and then on days 0, 6, 14, 16, 21, and 25 of gestation and on days 1 and 4 of lactation/postparturition.
MATING PERFORMANCE
- Mating performance was evaluated daily during the cohabitation period.
- Dams were evaluated daily during gestation for duration of gestation, maternal behaviour, litter size and pup viability. - Oestrous cyclicity (parental animals):
- Mating, day 0 of gestation identified on basis of spermatozoa in vaginal smear.
- Postmortem examinations (parental animals):
- SACRIFICE
- Dams that did not deliver litters were sacrificed on day 25 of presumed gestation and dams that did deliver litters were sacrificed on days 4 or 5 of lactation. All dams were examined for gross lesions and implantation sites.
GROSS NECROPSY
- Ovaries from all dams and any observed gross lesions were preserved in neutral 10% formalin for possible evaluation. - Postmortem examinations (offspring):
- GROSS NECROPSY
- Vital signs at birth were determined for pups that were stillborn or died before the initial examination of the litter.
- Each litter was evaluated for viability a minimum of twice daily during the 4-day lactation period.
- Dead pups were removed and necropsied.
- Tissues with gross lesions were preserved for possible examination.
- Pups in each litter were counted and observed for nursing behaviour and physical abnormalities daily.
- Pup body weights were measured on days 1 and 4 of postpurition. - Statistics:
- Fisher's ANOVA followed by Dunnett's test
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation (if dermal study):
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- effects observed, treatment-related
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- not examined
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 200 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 1 500 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- Clinical signs:
- no effects observed
- Dermal irritation (if dermal study):
- no effects observed
- Mortality / viability:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, non-treatment-related
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings:
- not examined
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Key result
- Dose descriptor:
- NOEL
- Generation:
- F1
- Effect level:
- 200 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- Reproductive effects observed:
- not specified
- Conclusions:
- The test substance was assessed for toxicity to reproduction using a one-generation study in rats. The results showed that under the conditions of the test, dose levels of 200 mg/kg bw/day of the test substance had no significant adverse effects on the reproductive performance of female Sprague-Dawley rats or the growth or development of their offspring.
- 1 and 3 deaths were reported in the 1000 and 2000 mg/kg bw/day dose groups, respectively.
CLINICAL SIGNS
- Clinical signs at 200 mg/kg bw/day in dams during premating and gestation included a significant increase in rales (P<0.01). This effect was not
reported during the lactation period. In the 1000 and 2000 mg/kg bw/day dose group, significant increases in the incidence of rales (P<0.01), excess salivation (P<0.01) was reported during premating and gestation. Excess salivation continued during lactation in the high-dose group.
- Other significant (P<0.01) effects during gestation in the high-dose group included decreased activity, ungroomed coat and labored breathing.
BODY WEIGHTS
- The 2000 mg/kg bw/day group showed reduced body weight gains during premating, and significantly (P<0.05 to <0.01) decreased average maternal body weights on days 10 and 16 of gestation.
FOOD CONSUMPTION
- Average and relative food consumption was reduced in the high-dose group of dams throughout the study. The high dose also was associated with reduced mating and fertility that were related to mortality.
COHABITATION INDICES
-The duration of cohabitation and fertility and gestation indices 200, 1000, or 2000 mg/kg bw/day were not different from comparable indices in thee control group.
- The high-dose group exhibited reduced pup weights on day 4 postparturition.
OTHER
No biologically relevant or statistically significant differences in the number of implantations, duration of gestation, the percentage of dams delivering one or more live pups, and the pup viability index were observed.
GROSS PATHOLOGY
- No malformations or gross lesions were observed in pups at any dose levels.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The test substance was assessed for toxicity to reproduction using a one-generation study in rats using the analogue substances 2,6-dimethylhept-5-enal and Heptanoic acid. The results showed that under the conditions of the test, dose levels of 300 mg/kg bw/day of 2,6-dimethylhept-5 -enal and dose levels of 200 mg/kg bw/day of Heptanoic acid had no adverse effects on the reproductive performance of female Sprague-Dawley rats or the growth or development of their offspring.
The read-across are considered to be suitable based on the structural and “mechanistic action” similarities between the target substance (Nonanal) and source substances (2,6-dimethylhept-5-enal and Heptanoic acid) and their similar physico-chemical properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.