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EC number: 204-688-5 | CAS number: 124-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity weight of evidence approach was used. One study performed on the target substance gave an LD50 of 5000 mg/kg bw. Further studies on the analogue substance, decanal, gave an LD50 >33320 mg/kg bw in rats and 41750 mg/kg bw in mice.
Acute dermal toxicity weight of evidence approach was used. One study performed on the target substance gave an LD50 of 5000 mg/kg bw. Further studies on the analogue substances Octanal and Decanal gave LD50s of 6.85 mL/kg bw and 5.04 mL/kg bw respectively.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only.
- Qualifier:
- according to guideline
- Guideline:
- other: Paragraph 191.1(f)(1) of the Final Order, Enforcement Regulations, United States Federal Register. Vol. 26, No. 155, p. 7336, 1961-08-12
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 24 hours
- Diet: Available ad libitum
- Water: Available ad libitum
- Acclimation period: 1 week - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 animals/sex
- Control animals:
- no
- Details on study design:
- Animals were observed for 14 days.
- Statistics:
- None
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: Diuresis was noted soon after dosing followed by lethargy and dullness. Recovery was complete 24-48 hours after dosing.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was assessed for acute oral toxicity using rats exposed to the test material by oral gavage. The acute oral LD50 for the test material was >5000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study provides insufficient experimental detail and is therefore used as a weight of evidence.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of mice fed test material and observed for 14 d.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No
- Housing: In cages
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- No data
- No. of animals per sex per dose:
- 5 male, 5 female per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs - Statistics:
- LD₅₀ values were computed by the method of Litchfield & Wilcoxon (1949).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 41 750 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: Excitation, diarrhoea, wet fur on stomach and posterior
- Gross pathology:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity of the test substance was assessed in mice. The results determined that the acute oral LD₅₀ of decanal to mice was > 41,750 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study provides insufficient experimental detail and is therefore used as a weight of evidence.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of rats fed test material and observed for 14 d.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: approx. 18 hr
- Housing: In cages
- Diet: Ad libitum (except fasting period)
- Water: Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Doses:
- No data
- No. of animals per sex per dose:
- 5 male, 5 female per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs - Statistics:
- LD₅₀ values were computed by the method of Litchfield & Wilcoxon (1949).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 33 320 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Highest dose administered
- Mortality:
- No
- Clinical signs:
- other: Excitation, diarrhoea, wet fur on stomach and posterior
- Gross pathology:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity of the test substance was assessed in rats. The results determined that the acute oral LD₅₀ of decanal to rats was >33320 mg/kg bw (the highest dose administered).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Sedion 191.10 of the Final Order. Enforcement Regulations. United States Federal Register, Vol. 26, No. 155, p 7336 1961-08-12
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Aldehdyde C-9, EAO 71-14
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
- Other: Tested as supplied - Species:
- rabbit
- Strain:
- other: Albino (probably New Zealand White)
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: No data
- 3 rabbits' skin left intact; 3 rabbits' skin abraded.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
TEST MATERIAL
- Volume or weight applied: No data - Duration of exposure:
- Single exposure
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 6 animals (sex not specified) per single dose.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data - Statistics:
- None
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/6 (1 rabbit from abraded group died on day 4)
- Clinical signs:
- other: Severe oedema and burns
- Gross pathology:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was assessed for acute dermal toxicity in albino rabbits. The LD50 was > 5000 mg/kg body weight.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study provides insufficient experimental detail and is therefore used as a weight of evidence.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 1 day cuff method of Draize et al.
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2.5 to 3.5 kg
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Fur removed from entire trunk by clipping
- Animals immobilised during 24 hr contact period - Duration of exposure:
- 24 hr contact period
- Doses:
- Maximum dose 20 mL/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 d
- Statistics:
- Based on the mortality during the 14 d period, the most probable LD₅₀ value and its fiducial range was estimated using the method of Thompson using the Tables of Wiel. The limits, where appropriate, were calculated as ± 1.96 standard deviations.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5.04 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3.78 - <= 6.82
- Conclusions:
- The test substance was assessed for acute dermal toxicity in albino rabbits. The LD50 was 5.04 mL/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Acute oral toxicity
A weight of evidence approach was used for the assessment of the acute oral toxicity of the target substance. One study indicated the LD₅₀ of Nonanal was > 5000 mg/kg bw, however the study was of low reliability. Therefore data for two structural analogues, Octanal and Decanal were also presented. Further studies on the analogue substance, decanal, gave an LD50 >33320 mg/kg bw in rats and 41750 mg/kg bw in mice.The aldehydes are generally considered to be of low acute oral toxicity.
Acute inhalation toxicity
Due to the low vapour pressure of this substance, and the lack of systemic toxicity found in acute oral or dermal toxicity studies, inhalation toxicity can be disregarded. Additionally, data from Smyth et al. (1962) are presented for structurally-related aldehydes, Octanal and Decanal, indicates no toxicity for this substance. No mortality was observed for either substance up to exposures of 8 hrs to test material saturated in air.
Acute dermal toxicity
A weight of evidence approach was used for the assessment of the acute dermal toxicity of the target substance. One study indicated the LD₅₀ of Nonanal was > 5000 mg/kg bw, however the study was of low reliability. Therefore data for two structural analogues, Octanal and Decanal were also presented, with LD50s of 6.85 mL/kg bw and 5.04 mL/kg bw respectively. All available information supports the conclusion that the aldehydes, including Nonanal, are not acutely toxic via the dermal route.
Justification for selection of acute toxicity – oral endpoint
Study on substance itself
Justification for selection of acute toxicity – dermal endpoint
Study on substance itself
Justification for classification or non-classification
Based on the oral LD50 values of >5000 mg/kg bodyweight and dermal LD50 values of > 5000 mg/kg bodyweight, there is no need to classify Nonanal for acute to toxicity in accordance with the criteria outlined in Annex VI of 67/548/EEC (DSD) and Annex I of 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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