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EC number: 204-688-5 | CAS number: 124-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-05-30 to 2011-07-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Aldehyde C9 Nonylic Food Grade
- Physical state: Liquid
- Lot/batch No.: VE00120901
- Expiration date of the lot/batch: October 14, 2011 - Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
The test substance is not soluble enough in water to allow the preparation of an aqueous stock solution in tap water.
Different stock solutions were prepared by dissolution of Aldehyde C9 Nonylic Food Grade in ethanol in order to add always the same volume (ie 5 ml) of ethanol in each cylinder.
The following solutions were prepared:
A1: solution 100 mg of Aldehyde C9 Nonylic Food Grade in 10 ml ethanol
A2: solution 31.6 mg of Aldehyde C9 Nonylic Food Grade in 10 ml ethanol
A3: solution 10.0 mg of Aldehyde C9 Nonylic Food Grade in 10 ml ethanol
A4: solution 3.2 mg of Aldehyde C9 Nonylic Food Grade in 10 ml ethanol
A5: solution 1.0 mg of Aldehyde C9 Nonylic Food Grade in 10 ml ethanol - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The sludge was kept aerobic until being used on the same day. The pH was between 7 and 8.
The suspended solids content was determined by drying and weighing 50 ml of the sludge: dry weight of suspended solids: 16.76 g/l
By adding 200 ml of sludge to the 500 ml test vessels, the final concentration of suspended solids was 0.88 g/l, ie in the range 0.8 to 1.6 g/l as recommended in ISO 8192-1986 - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2°C
- pH:
- Refer to Table 1 test results
- Dissolved oxygen:
- Refer to Table 1 test results
- Nominal and measured concentrations:
- 1.0, 3.2, 10.0, 31.6 and 100 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 500 ml scaled cylinders
- Aeration: Yes - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 70 mg/L
- Nominal / measured:
- nominal
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 31.6 mg/L
- Nominal / measured:
- nominal
- Results with reference substance (positive control):
- - Results with reference substance valid? The reference substance showed 3.8 % inhibition at 5 mg/L and 72 % inhibition at 30 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was assessed for activated sludge respiration inhibition according to OECD 209. The EC50 (3 hours) of Aldehyde C9 Nonylic Food Grade is ~ 70 mg/l. The NOEC is 31.6 mg/L.
Reference
Table 1: Test results
vessel |
pH |
∆O2 [mg/l] |
Time [min] |
rate |
% inhibition |
Conc.finale [mg/l] |
Log (conc) |
C1 |
8.54 |
1.90 |
2.50 |
0.76 |
- |
- |
- |
Tr |
8.72 |
2.05 |
2.50 |
0.82 |
- |
- |
- |
R1 |
8.54 |
1.90 |
2.50 |
0.76 |
3.8 |
5.0 |
0.70 |
R2 |
8.56 |
0.55 |
5.00 |
0.22 |
72.2 |
30.0 |
1.48 |
S1 |
8.56 |
0.85 |
5.00 |
0.17 |
78.5 |
100.0 |
2.00 |
S2 |
8.53 |
1.95 |
5.00 |
0.78 |
1.3 |
31.6 |
1.50 |
S3 |
8.45 |
1.95 |
5.00 |
0.78 |
1.3 |
10.0 |
1.00 |
S4 |
8.60 |
1.90 |
2.50 |
0.76 |
3.8 |
3.2 |
0.51 |
S5 |
8.60 |
1.95 |
5.00 |
0.78 |
1.3 |
1.0 |
0.00 |
Only at a test concentration of 100 mg/l a significant inhibition of the respiration was observed. For estimating the EC50 (3 hours) a linear relationship between % inhibition and the common logarithm of the test substance concentration was assumed for concentrations ranging from 31.6 mg/l (test vessel S2) to 100 mg/l (test vessel S1). A linear regression was performed (least squares method) and parameters a and b were obtained:
% inhibition = a * log conc. + b
a = 103.269 b = -136.537
Using the equation and parameters above, the concentration corresponding to an inhibition of 50% was calculated EC50 = ~ 0.7 . 102mg/l
Description of key information
The test substance was assessed for activated sludge respiration inhibition according to OECD 209. The EC50 (3 hours) of Aldehyde C9 Nonylic Food Grade is ~ 70 mg/l. The NOEC is 31.6mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 70 mg/L
- EC10 or NOEC for microorganisms:
- 31.6 mg/L
Additional information
The test substance was assessed for activated sludge respiration inhibition according to OECD 209. Five concentrations were tested: 1, 3.2, 10, 31.6 and 100mg/L. Only at a test concentration of 100 mg/L was significant inhibition of the respiration observed. Therefore the NOEC is considered to be 31.6 mg/L. For estimating the EC50 (3 hours) a linear relationship between % inhibition and the common logarithm of the test substance concentration was assumed for concentrations ranging from 31.6 to 100mg/l. Using this equation the concentration corresponding to 50% inhibition was calculated to be ~ 70 mg/l.
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