Registration Dossier
Registration Dossier
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EC number: 204-514-8 | CAS number: 122-00-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A study was performed to assess the skin sensitisation potential of 4'-methylacetophenone in the Hartley guinea pig by the method similar to OECD TG 406 (Sharp 1978). 10 animals were injected with 0.5 % substance in solution at 4 sites which overlie the 2 auxillary and 2 inguinal lymph nodes. Fourteen days later each animal was challenged intradermally in one flank and topically in the other with 0.1 mL aliquots of test substance at the level of 0.2 % and 20 %, respectively. The test substance 4'-methylacetophenone was considered as non-sensitising to the skin in this modified Draize sensitisation test. In addition, open epicutaneous test with 6 male and female guinea pigs showed that 4'-methylacetophenone is not sensitising to the skin (Klecak 1985).
Migrated from Short description of key information:
4'-methylacetophenone showed no sensitising potential in guinea pigs.
Justification for selection of skin sensitisation endpoint:
Principles of this study are comparable to those of OECD TG 406.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
not required
Justification for classification or non-classification
- skin sensitisation:
Based on the above stated assessment of the skin sensitisation potential, 4'-methylacetophenone does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) or according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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