Registration Dossier
Registration Dossier
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EC number: 204-514-8 | CAS number: 122-00-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Read-across studies from acetophenone are possible to cover 4'-methylacetophenone toxicokinetic data gaps.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No ADME and dermal absorption studies with 4 -methylacetophenone are available.
However, a series of acute toxicity studies give an indication about the bioavailability after oral and dermal application. In one acute and one repeated dose oral toxicity studies with 4-methylacetophenone systemic toxicity was seen leading to the conclusion that the test substance is bioavailable after oral application.
After dermal application of 2000 mg test substance/kg bw in a rabbit acute toxicity study and dermal application in two guinea pig sensitization studies no systemic effects could be observed. The octanol/water partition coefficient of 2.1 (25°C) indicates low lipophilic property of the substance and, also considering the low molecular weight of 134.19 g/mol it can be assumed that the substance penetrates to low extend though the skin.
The substance 4-methylacetophenone is a liquid at room temperature with the vapour pressure of 52 Pa. Inhalation exposure might be possible via evaporation and as aerosol.
Since the toxicokinetic data of the 4’-methylacetophenone are very scarce, for providing further supporting evidence acetophenone was chosen as read across compound (Adams 2007, El Masry 1956, Quiek 1928, Smith 1954, Sullivan 1976).
In contrast to acetophenone in 4’-methylacetophenone an additional methyl group in para position of the benzene ring occurs. This lipophilic group adds to the already lipophilic benzene ring and does not significantly influence the polarity of the molecule. The methyl group is not considered to be an active benzene ring substitute in animals and humans and cleavage during metabolism is not expected. The carbonyl group undergoes metabolic transformation in the similar way as for acetophenone (Williams, 1940). Metabolites of 4-methylacetophenone are excreted in the urine predominantly as the glucuronic acid conjugate.Therefore we can assume that read-across studies from acetophenone are possible to cover 4'-methylacetophenone toxicokinetic data gaps.
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