Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Transformation products:
no
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
20 °C
Remarks on result:
not measured/tested
Key result
pH:
4
Temp.:
50 °C
Remarks on result:
not measured/tested
Key result
pH:
4
Temp.:
70 °C
Remarks on result:
not measured/tested
Key result
pH:
7
Temp.:
20 °C
Hydrolysis rate constant:
0.805 h-1
DT50:
0.9 h
Key result
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
2.574 h-1
DT50:
0.3 h
Key result
pH:
7
Temp.:
70 °C
Hydrolysis rate constant:
2.574 h-1
DT50:
0.3 h
Key result
pH:
9
Temp.:
20 °C
Hydrolysis rate constant:
0.006 h-1
DT50:
11.9 h
Key result
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.177 h-1
DT50:
3.9 h
Key result
pH:
9
Temp.:
70 °C
Hydrolysis rate constant:
1.248 h-1
DT50:
0.6 h

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
hydrolytically unstable at ph4, ph7 and ph9
Executive summary:

hydrolytically unstable at ph4, ph7 and ph9