Registration Dossier
Registration Dossier
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EC number: 619-946-6 | CAS number: 890707-29-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- other: Study report - Ownership of data to be determined
- Adequacy of study:
- supporting study
- Study period:
- 2010-2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- 2-amino-5-cyano-N,3-dimethylbenzamide
- EC Number:
- 619-946-6
- Cas Number:
- 890707-29-6
- Molecular formula:
- C10H11N3O
- IUPAC Name:
- 2-amino-5-cyano-N,3-dimethylbenzamide
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 6.46 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- female
- Basis for effect level:
- clinical signs
- mortality
- urinalysis
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 5.82 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- male
- Basis for effect level:
- clinical signs
- mortality
- urinalysis
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 62.5 ppm
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- mortality
- urinalysis
Applicant's summary and conclusion
- Conclusions:
- NOAEL was estimated to be 6.43±0.13 mg&kg/day in female rats and 5.82±0.31 in male rats.
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