Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 480-880-4 | CAS number: 608-23-1
Endpoint summary
Administrative data
Description of key information
3-Chloro-o-xylene is hydrolytically stable (OECD 111, 2004).
Additional information
A reliable key study was conducted according to OECD TG 111, hydrolysis screening test (RL1, 2004). The study was conducted in compliance with GLP. The HPLC results indicated that the observed test item concentrations in heated and frozen test solutions were lower than nominal. However, this was not due to the hydrolysis of 3-chloro-o-xylene, because no hydrolysis product was detected. These lower-than-nominal test item concentrations were likely due to the adsorption of 3-chloro-o-xylene to the vial glass, which was supported by results from an additional adsorption experiment. The adsorption experiment examined the effect of varying co-solvent concentrations on the observed test item concentration in pH 9 buffer solutions. In fact, the observed test item concentration generally decreased as the acetonitrile concentration decreased. Therefore, it was concluded that based on the results of the study, 3-chloro-o-xylene was hydrolytically stable (half-life > 1 year at 25 °C). Despite of minor deviation from the test guideline, results of the study were considered reliable and adequate for the environmental hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
