Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Study period:
before July 1975
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation of composition/type of substance is insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity not specified
Specific details on test material used for the study:
Information from study report:
Alkansulfonate, technical product, 93.3 %, white large crystals

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
2 other: mg/kg bw, substance applied as 0.2% aqueous solution
Basis for effect level:
dermal irritation
other: Basis for effect level: After repeated treatment with 250 mg/kg bw (applied as 25% aqueous solution) oedema, corrosivity and necrosis at site of application was reported. No effects indicating systemic toxicity were reported.

Target system / organ toxicity

Critical effects observed:
yes
Organ:
skin

Applicant's summary and conclusion