Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 426-730-3 | CAS number: 123439-82-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 June 1997 - 7 July 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP, with a slight deviation from the recommended humidity range
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- relative humidity was above the recommended range stated in the guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- relative humidity was above the recommended range stated in the guideline
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetramine platinum hydrogencarbonate
- IUPAC Name:
- Tetramine platinum hydrogencarbonate
- Reference substance name:
- 123439-82-7
- Cas Number:
- 123439-82-7
- IUPAC Name:
- 123439-82-7
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Tetramine platinum hydrogencarbonate
- Substance type: No data
- Physical state: white powder
- Analytical purity: >99.9%
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: Tetramine platinum hydrogen carbonate (>99.9%)
- Isomers composition: Not applicable
- Purity test date: No data
- Lot/batch No.: 02/95
- Expiration date of the lot/batch: 31/12/1999
- Stability under test conditions: stable throughout the experimental period
- Storage condition of test material: closed container at room temperature
- Other: pH was about 8 (concentrated solution)
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White russian (albino)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: ASTA Medica AG, D-33790 Halle/Westfalen
- Age at study initiation: 39-41 months
- Weight at study initiation: 2.07-2.96 kg
- Housing: stainless steel cages with grating floor, one animal per cage
- Diet (e.g. ad libitum): 120 g/animal each day (sniff K-Z, complete diet for rabbits-breeding)
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: at least one day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5-20.5 deg C
- Humidity (%): 53-84% (recommended humidity range is 30-70%. The peak may have occurred during room cleaning i.e. only for a short period of time. It is therefore considered not to compromise the validity of the results.)
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 9 June 1997 To: 7 July 1997
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye acted as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 90.1, 106.9 or 107.1 mg (representing a volume of about 0.1 mL)
- Concentration (if solution): Not applicable
VEHICLE
- Amount(s) applied (volume or weight with unit): Not applicable
- Concentration (if solution): Not applicable
- Lot/batch no. (if required): Not applicable
- Purity: Not applicable - Duration of treatment / exposure:
- 21 days
- Observation period (in vivo):
- Observed at 1, 24, 48 and 72 hrs, then daily until day 21.
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): treated eye was not rinsed
- Time after start of exposure: Not applicable
SCORING SYSTEM: DRAIZE scale
TOOL USED TO ASSESS SCORE: Cliptrix pencil light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 20
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: In one animal only were the findings not reversible within 21 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 6.7
- Max. score:
- 80
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 2.1
- Max. score:
- 10
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 11.2
- Max. score:
- 20
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: corneal opacity
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: iris evaluation
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 0.4
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- other: conjunctival redness score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: conjunctival chemosis score
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritant / corrosive response data:
- Diffuse corneal opacity was observed in two animals 48 hours after application, in one animal this disappeared after 6 days while the other showed translucent opacity by day 10. The corneal area involved was greater than three quarters in both animals. The cornea of the third animal was unremarkable. Slight to moderate circumcorneal hyperemia was apparent in two animals, lasting from 2 to 6 days or 1 to 10 days after application respectively. The iris of the third animal was unremarkable. The conjunctivae of all three animals were hyperemic immediately after application. In one animal the findings had completely disappeared by day 7, while the other two animals showed worsening up until 3 or 4 days after application with the former showing reversibility by day 9 while the latter persisted the entire 21-day observation period. Swelling (including nicitating membranes) occurred in all three animals, and persisted in one animal until day 21.
- Other effects:
- The general condition of the animals was undisturbed. Conjunctival discharge was observed in all three animals at 1 hr and lasted until days 6, 8 and 21 (still present at the end of the observation period) respectively. Signs of irritancy aggravated during the course of the study and one animal showed an irreversible effect in the course of the 21 day observation period. Nevertheless, according to the study report "the development of the findings towards the end of the study indicates a tendency to reversibility" and thus do not justify a diagnosis of "severe eye lesions".
Any other information on results incl. tables
Table 1: Mean eye irritation scores for each animal
Animal | Mean 1-72 hours | |||
Corneal opacity | Iris | Conjunctivae | ||
Redness | Chemosis | |||
1 | 0.7 | 0.7 | 2.0 | 1.7 |
2 | 0.0 | 0.0 | 1.7 | 0.7 |
3 | 0.7 | 1.0 | 1.7 | 2.7 |
Mean | 0.3 | 0.4 | 1.7 | 1.3 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- In a guideline study (OECD TG 405), to GLP, tetraammineplatinum(II) hydrogencarbonate produced slight irritation following instillation of the test material (0.1 mL) to the eyes of three rabbits. Effects in one animal persisted until the end of the observation period, though the development of these findings indicated a tendency to reversibility.
- Executive summary:
In an OECD guideline study (TG 405), conducted according to GLP, tetraammineplatinum(II) hydrogencarbonate (90.1, 106.9 or 107.1 mg, representing a volume of about 0.1 mL) was instilled into one eye of each of three male white Russian rabbits. The other eye remained untreated and was used for control purposes.
Corneal irritation was observed in two out of the three animals after 2 days. Within 6 days the effects in one animal were resolved while the effects in the other animal were still present at the end of the 21-day observation period. Iris irritation was also observed in two out of the three animals, with effects lasting until days 6 and 10 respectively. Conjunctival irritation, consisting of redness, chemosis and discharge, was observed in all three animals. In two animals, this had completely resolved within 6 and 8 days respectively while the effects in the other animal persisted until the end of the observation period. The test material produced an overall eye irritation index score of 20.0 [maximum total score possible = 110] (mean of the scores 1 -72 hr) and was classified as slightly irritant to the rabbit eye according to a modified Draize classification system. The general condition of the animals was not adversely affected. In spite of the persistent effects observed in one animal, the development of these findings towards the end of the observation period indicated a tendency to reversibility.
Nevertheless, based on the persistent effects observed in one animal in this study, the test material should be classified for serious eye damage (category 1) according to EU CLP criteria (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.