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EC number: 203-916-0 | CAS number: 111-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The test substance was administered orally at a dose level of 200 mg/kg bw to 5 male and 5 female rats. The animals were then observed for 21 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Octylamine
- EC Number:
- 203-916-0
- EC Name:
- Octylamine
- Cas Number:
- 111-86-4
- Molecular formula:
- C8H19N
- IUPAC Name:
- octan-1-amine
- Details on test material:
- - Name of test material (as cited in study report): n-Octylamin
- Physical state: liquid
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH
- Age at study initiation: young adults
- Weight at study initiation: mean males: 191 g; mean females: 179 g
- Fasting period before study: the animals were given no feed about 16 hours before administration
- Housing: 5 animals/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 0.26 ml/kg
- Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing: recording of signs and symptoms several times on the day of administration and at least once each workday; Check for moribund and dead animals twice each workday and once on holidays. Weighing was performed on day 0, day 6, day 13, day 20.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 200 mg/kg bw
- Mortality:
- 2/5 male animals and 5/5 female animals died
- Clinical signs:
- other: male animals: poor general state, dyspnoea, apathy, staggering, piloerection, exsiccosis, salivation, weight reduction, discoloured urine (red) female animals: poor general state, dyspnoea, apathy, staggering, piloerection, smeared fur, exsiccosis, weight
- Gross pathology:
- animals that died: general congestion
lungs: intensified emphysema in one animal, emaciation in two animals; these two animals died after 10 and 20 days.
sacrificed animals:
no pathologic findings noted
Any other information on results incl. tables
Mortality
Dose (mg/kg) | No. of animals | Died within1h | 1 day | 2 days | 7 days | 14 days | 21 days |
200 | 5 male | 0 | 1 | 1 | 1 | 1 | 2 |
200 | 5 female | 2 | 4 | 4 | 4 | 4 | 5 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of n-octylamine was determined to be below 200 mg/kg.
- Executive summary:
In a non-GLP study that was conducted similar to OECD TG 401, n-octylamine was administered at 200 mg/kg bw by oral gavage to male and female rats (5 animals per sex and dose) that were fasted 16 h before administration. Signs of toxicity included poor general state, dyspnoea, apathy, staggering, piloerection, exsiccosis, salivation, weight reduction, discoloured urine (red), smeared fur, and snout red crusted. At 200 mg/kg bw, 2/5 male animals and 5/5 female animals died. Gross lesions of the animals that died included general congestion, intensified emphysema (one animal), and emaciation (two animals) of the lungs. The acute oral LD50 in rats was below 200 mg/kg bw (BASF, 1990).
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