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Diss Factsheets
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EC number: 203-915-5 | CAS number: 111-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Proposed Guidelines of the US EPA Paragraph 163.81-5 "Primary Dermal Irritation Study", Federal register, Vol. 43, No. 163, August 22, 1978
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Procedure as given in guideline cited. Scoring of skin effects according to Draize (1959).
- GLP compliance:
- no
- Remarks:
- no GLP implemented at that time
Test material
- Reference substance name:
- 1-chlorooctane
- EC Number:
- 203-915-5
- EC Name:
- 1-chlorooctane
- Cas Number:
- 111-85-3
- Molecular formula:
- C8H17Cl
- IUPAC Name:
- 1-chlorooctane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, Fuellingsdorf, Switzerland
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.3-3.0 kg
- Housing: individually in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 20. August 1981 To: 01. September 1981
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 21 days
- Number of animals:
- 6
- Details on study design:
- The test was conducted on intact and abraded skin.
TEST SITE
- Area of exposure: back and flank (one side was slightly scarified by making minor incisions through the stratum corneum)
- % coverage: 2.5 x 2.5 cm
- Type of wrap if used: test item applied under a patch of surgical gauze and covered with aluminium foil; then the trunk of the animals wrapped with an occlusive bandage of elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing : not reported
OBSERVATION SCHEDULE:
- immediately; 48 and 72 hours; 4, 7, 14 and 21 days, unless the skin is normal at 7 or 14 days
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.72
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.44
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: intact skin
- Other effects:
- No acute toxicological signs were observed in the animals during the test period. After 7 days one rabbit showed necrosis of the skin at the application area.
Any other information on results incl. tables
The test substance showed a slight skin irritation when applied to intact and abraded skin. For intact skin the mean erythema score after 24, 48 and 72 hours was 1.72/4 and the respective mean edema score 0.44/4.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the study the test item showed a slight skin irritation potential on intact and abraded rabbit skin. For intact skin the mean erythema score after 24, 48 and 72 hours was 1.72/4 and the respective mean edema score 0.44/4.
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