Registration Dossier
Registration Dossier
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EC number: 203-915-5 | CAS number: 111-85-3
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence:
According to the biodegradation key study (MITI test according to OECD guideline 301 C) the substance revealed a biodegradation (BOD) of 74% to 81% after 28 days.The biodegradability by GC was determined to 100% proving the test item to be readily biodegradable. Therefore, the substance does not fulfill the P-criterion.
Bioaccumulation:
An experimental logKow is 3.79 indicating that the B-criterion is not fulfilled. Further,for 1,8 -dichlorooctan (CAS 2162 -99 -4) a study in accordance with OECD 305 C (flow-through study over 8 weeks, 2 concentrations tested, test design improved for a volatile substance) is available. 1,8-dichlorooctane is structurally very similar to n-Octyl chlorid and has even a higher calculated logKow value (4.78 calculated with KOWWIN v1.68) than n-Octyl chlorid (4.52 calculated with KOWWIN v1.68). In contrast to n-Octyl chlorid, 1,8 -dichlorooctane is not readily biodegradable according to the disseminated REACH dossier at the ECHA website. Therefore, using bioaccumulation data from 1,8-dichlorooctane for predicting the bioaccumulation potential of n-Octyl chlorid can be regarded as a worst case approach. With BCFs of 148 -409 for the 0.01mg/L concentration and 281 -692 for the 0.1 mg/L concentration, the study clearly indicates that 1,8-dichlorooctan and therefore also n-Octyl chlorid does not fulfill the B-criterion (BCF <2000).
Toxicty:
Chronic studies for algae, daphnia and fish are available. The resulting NOECs are above 0.01 mg/L. The substance does not require classification as carcinogenic Cat. 1. or 2, mutagenic Cat 1. or 2, or toxic for reproduction Cat. 1, 2 or 3 according to Directive 67/548/ EEC (DSD) nor as carcinogenic Cat. 1 A or 1B, germ cell mutagenic Cat. 1A or 1B, or toxic for reproduction Cat. 1A, 1B or 2 according to Regulation EC No 1272/2008 (CLP-Regulation). The substance does not exhibit any othere evidence of chronic toxicity, as identified by the classifications T, R48 or Xn according to Directive 67/548/ EEC (DSD) or specif target organ toxicity after repeated exposure (STOT RE Cat. 1 or 2) according to Regulation EC No 1272/2008 (CLP-Regulation). Therefore, the substance does not fulfill the T-criterion.
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