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EC number: 944-817-9
CAS number: 244626-73-1
a limit acute dermal toxicity study performed according to the EU B.3
test method and in compliance with GLP, young adult Crl:CD(SD)BR (VAF
plus) rats were occlusively exposed to undiluted test material for 24
hours at dose of 2000 mg/kg bw. In a preliminary range-finding study,
the test material was administered to one male and one female rat. Both
of these animals appeared outwardly healthy throughout the 7 day
observation period. In the main study, the test material was
administered to 5 males and 5 females. After 24 hours, the dressings
were removed and the treated sites were washed with warm water. The
animals were observed for 14 days and at the end of this period they
were killed and necropsied.
deaths occurred and all animals remained outwardly healthy throughout
the study. There was no adverse effect on bodyweight gain in animals of
either sex. Necropsy findings were of low incidence and are considered
not to be treatment related.
LD50Combined > 2000 mg/kg bw
the test conditions, the test material is not classified according to
the annex VI of the Regulation EC No. 1272/2008 (CLP).
study is considered as acceptable and satisfies the requirement for
acute dermal toxicity endpoint.
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