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EC number: 944-817-9
CAS number: 244626-73-1
assess the short-term toxicity of the registered substance to aquatic
organisms, experimental studies of reliability 1 (Klimisch rating),
based on international guidelines, are available on the three aquatic
trophic levels (algae, aquatic invertebrate and fish).Among all
acute data available, the fish Danio rerio is the most sensitive
species with a 96h-LC50 at 1.1 mg/L based on mean measured
concentrations. For the aquatic invertebrateDaphnia magna, the
48h-EC50 was determined to be 1.6 mg/L based on mean measured
concentrations, and for the algae Pseudokirchneriella subcapitata,
the 72h-ErC50 and ErC10 (based on growth rate) were determined to be
5.71 mg/L and 1.38 mg/L, respectively, based on initial measured
In addition, to assess the toxicity of the
registered substance to microorganisms, one experimental study of
relability 2 (Klimisch rating), based on international guideline, is
available on Pseudomonas
putida. None of the concentrations tested between 0.05 and 10 mgL
resulted in an inhibition of bacterial growth of P. putida after
16 hours of exposure. Therefore, the 16h-NOEC is equivalent to 10 mg/L
for this bacterial strain. However, considering the toxicity
effect observed in the biodegradation studies mentioned in the present
dossier, the toxic effect observed in activated sludge micro-organisms
up to 84 days at the tested concentration of 2 mg/L (AkzoNobel (2012)
OECD 301D study) is considered relevant for chemical safety assessment.
Therefore, the estimated NOEC for the toxicity to STP micro-organisms
can be expected at 1.0 mg/L (by dividing the toxic concentration by 2).
In the absence of any ecotoxicological data
for sediment-dwelling/soil organisms, the PNEC sediment/soil were
calculated using the equilibrium partitioning method (EPM). Furthermore,
no toxicity studies reporting the secondary poisoning effects on bird
were available, therefore the sub-chronic 90 days toxicity study on rats
was used to derive the PNECoral.
Environmental fate and pathways
The registered substance is
hydrolytically stable at any pH (from 2 to 12) and not readily
in the absence of valid simulation studies, the registered substance can
be considered as potentially persistent (potential P) or potentially
very persistent (potential vP) in the environment. With an
experimental BCF comprised between 46 and 60, the registered substance
is not bioaccumulable. Finally, the substance is slightly mobile
in soils with an adsorption coefficient estimated
at 2013 L/Kg (log Koc = 3.30).
No harmonised classification is
- lowest L(E)C50 value comprised
between 1 and 10 mg/L;
- ErC10 algae > 1 mg/L;
- Not rapidly degradable;
- experimental BCF = 46 -60.
according to the Annex VI of the Regulation (EC) No 1272/2008 (CLP): The
registered substance is classified as Aquatic Chronic 2 for the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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