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EC number: 237-706-5 | CAS number: 13933-32-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data (Report date March 1977)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not carried out to modern guidelines; not according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Register 37, No. 83, 28 April 1972, 191. 12
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraammineplatinum dichloride
- EC Number:
- 237-706-5
- EC Name:
- Tetraammineplatinum dichloride
- Cas Number:
- 13933-32-9
- Molecular formula:
- Cl.1/2H12N4Pt
- IUPAC Name:
- Tetraammineplatinum dichloride
- Details on test material:
- - Name of test material (as cited in study report): tetrammine platinous chloride
- Substance type: white powder
- Physical state: solid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data (supplied in plastic container)
- Other:
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: “recognised breeder”
- Age at study initiation: 12-14 weeks
- Weight at study initiation: mean 1.9 kg
- Housing: caged singly; no further data
- Diet (e.g. ad libitum): conventional diet; ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 ± 2
- Humidity (%): 50-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): natural lighting
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes, concurrent no treatment to left eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg into the right eye
VEHICLE
none - Duration of treatment / exposure:
- Group 1: 5 min (5 animals); Group 2: 24 hr (3 animals)
- Observation period (in vivo):
- 1, 24, 48, and 72 hr, then daily for a further 4 days
- Number of animals or in vitro replicates:
- 8 females (5 with 5 min exposure (Group 1); 3 with 24 hr exposure (Group 2))
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Group 1 - eyes rinsed after 5 mins
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 13.2
- Max. score:
- 65
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: 4/5 gave positive response at 24 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Group 1 - eyes rinsed after 5 mins
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 0
- Max. score:
- 20
- Irritation parameter:
- iris score
- Remarks:
- Group 1 - eyes rinsed after 5 mins
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Remarks:
- (Redness) Group 1 - eyes rinsed after 5 mins
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 7.2
- Max. score:
- 15
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Remarks:
- Group 1 - eyes rinsed after 5 mins
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 5.8
- Max. score:
- 20
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Remarks:
- Group 2 - eyes rinsed after 24 hours
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 13.7
- Max. score:
- 65
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: 3/3 gave positive response at 24 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Group 2 - eyes rinsed after 24 hours
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 0
- Max. score:
- 20
- Irritation parameter:
- iris score
- Remarks:
- Group 2 - eyes rinsed after 24 hours
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Remarks:
- (Redness) Group 2 - eyes rinsed after 24 hours
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 7
- Max. score:
- 15
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Remarks:
- Group 2 - eyes rinsed after 24 hours
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours & 7 days
- Score:
- 6.7
- Max. score:
- 20
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Group 1 Rabbits (eyes rinsed after 5 mins): Four out of five animals gave a positive response at the 24 hour observation. the reaction reduced and no positive reaction was apparent at 7 days.
Group 2 Rabbits (eyes rinsed after 24 hours): All three animals gave a positive response at the 24 hour observation. The reactions reduced and all eyes were clear at 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- In a US guideline study, instillation of tetraammine platinous chloride (0.1 g) to the right eye of eight rabbits for 5 min or 24 hr caused irritation which was fully reversible within 7 days.
- Executive summary:
In a US guideline study, the eye irritant potential of tetraammine platinous chloride was assessed in eight female New Zealand white rabbits. A group of three rabbits received a 0.1 g instillation of the powdered test material to the right eye. After 24 hr the eyes were rinsed and the animals were observed for up to 7 days. Another group of five rabbits were subject to the same procedure though the eye was rinsed after 5 minutes.
Redness and swelling of the conjunctiva occurred within 1 hr of exposure in both groups, and was fully reversible within 7 days. No effects were evident in the iris or cornea within the observation period. No differences in the severity of the conjunctival effects were apparent for the two exposure times.
Based on the results of this study, the test material should be classified as an eye irritant (category 2) under EU CLP criteria (EC 1272/2008).
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