Registration Dossier
Registration Dossier
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EC number: 200-908-9 | CAS number: 75-85-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- The Metabolism of Aliphatic Alcohols. The Glucoronic Acid Conjugation of Acyclic Aliphatic Alcohols
- Author:
- Kamil, I.A. et al.
- Year:
- 1 953
- Bibliographic source:
- Biochem. 53, 129 - 136
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylbutan-2-ol
- EC Number:
- 200-908-9
- EC Name:
- 2-methylbutan-2-ol
- Cas Number:
- 75-85-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-2-ol
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
441 mg/kg bw
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- After a single gavage of 441 mg/kg bw test item to rabbits 57.5 % was urinary excreted within 2 days p.a.
- Type:
- metabolism
- Results:
- The substance as a conjugate with glucuronic acid was identified in urine
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- After a single gavage of 441 mg/kg bw test item to rabbits 57.5 % was urinary excreted within 2 days p.a.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The substance as a conjugate with glucuronic acid was identified in urine
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
The toxicokinetic behaviour of the test item was examined. After a single gavage of 441 mg/kg bw of the test item to rabbits 57.5 % was urinary excreted within 2 days p.a. The substance as a conjugate with glucuronic acid was identified in urine. - Executive summary:
The toxicokinetic behaviour of the test item was examined. A single exposure was given to rabbits to determine the metabolism of the test item. After a single gavage of 441 mg/kg bw of the test item to rabbits 57.5 % was urinary excreted within 2 days p.a. The substance as a conjugate with glucuronic acid was identified in urine.
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