2-methylbutan-2-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: only secondary literature

Data source

Reference

Reference Type:

review article or handbook

Title:

Patty's Industrial Hygiene and Toxicology

Author:

Rowe and McCollister

Year:

1982

Bibliographic source:

Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute inhalation toxicity, no further details

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylbutan-2-ol

EC Number:

200-908-9

EC Name:

2-methylbutan-2-ol

Cas Number:

75-85-4

Molecular formula:

C5H12O

IUPAC Name:

2-methylbutan-2-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of inhalation exposure:

not specified

Vehicle:

not specified

Duration of exposure:

6 h

Concentrations:

Nominal concentrations: 15800; 5700; 3000 and 1100 ppm (57; 20.6; 10.8; 4 mg/L)

No. of animals per sex per dose:

4

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LC100

Effect level:

5 700 ppm

Exp. duration:

6 h

Remarks on result:

other: 20.6 mg/L

Effect levels 2

Sex:

not specified

Dose descriptor:

LC50

Effect level:

>= 3 000 - <= 5 700 ppm

Exp. duration:

6 h

Remarks on result:

other: between 20.6 and 10.8 mg/L

Mortality:

At top level all animals dead.
5700 ppm: All were dead within 24 hours

Clinical signs:

other: Motor incoordination

Body weight:

Loss of body weight

Gross pathology:

no data

Other findings:

no data

Any other information on results incl. tables

15800 ppm (57 mg/L) : At the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours. 5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure. 3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were als unconscious at the end of the exposure, lost weight for a few days and then recovered and survived. 1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute inhalation toxicity of the test item was determined. The LD50 was determined to be between 3000 and 5700 ppm (equivalent to 10990.556 and 20882.057 mg/m^3)

Executive summary:

The acute inhalation toxicity of the test item was determined. The standard acute method was conducted with 4 rats. Nominal concentration of 15800, 5700, 3000 and 1100 ppm (57, 20.6, 10.8 and 4 mg/L) were used. The rats were exposed to the test item over a period of 6 h. As a result the LC100 was determined to be 5700 ppm and the LC50 was determined to be between 3000 and 5700 ppm (equivalent to 10990.556 and 20882.057 mg/m^3). Furthermore at the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours. 5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure. 3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were als unconscious at the end of the exposure, lost weight for a few days and then recovered and survived. 1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.