Registration Dossier

Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards. Only abstract available.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: XTT assay
Principles of method if other than guideline:
XTT assay with human gingival fibroblasts (HGF).
GLP compliance:
not specified
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Substance: Ethyltriglycol methacrylate (ETMA)
- Purity: not specified, but commercial grade assumed

Results and discussion

Details on results:
The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was EC50 (half-maximum effect concentration): 12.000 mmol/L ((1.100 standard deviation) according to XTT assay.

Applicant's summary and conclusion

Conclusions:
The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was EC50 (half-maximum effect concentration): 12.000 mmol/L ((1.100 standard deviation) according to XTT-based cell viability assay.
Executive summary:

The Cytotoxic effect of Ethyltriglycol methacrylate on human gingival fibroblasts (HGF) was assessed XTT-based cell viability assay. Each experiment was performed at least four times. The EC50 for Ethyltriglycol methacrylate was determined to be 12.000 mmol/L ((1.100 standard deviation).